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Cat. No.: HY-W995241

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BPD

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

BPD is a COX-2 and TAK1-NF-κB inhibitor, with an IC₅₀ of 18.5 μM for COX-2. BPD inhibits the expression of iNOS, TNF-α, IL-6 and IL-1β at the transcriptional level. BPD has anti-inflammatory activity. BPD can inhibit Carrageenan-induced paw oedema and LPS-induced septic death.

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CAS No.: 213481-12-0
Formule: C₁₇H₁₀O₅
Masse moléculaire:294.26

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

BPD Chemical Structure

CAS No.: 213481-12-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- Essai clinique
Chemical Information
Publications (1)
Pureté et documentation
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Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform COX :

Voir tous les produits spécifiques à Isoform NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	328.68 μM Compound: 5a	Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 20004572]
RAW264.7	IC₅₀	7.13 μM Compound: 5a	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production by EIA Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production by EIA	[PMID: 20004572]

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 213481-12-0
Masse moléculaire 294.26
Formule C₁₇H₁₀O₅
SMILES

O=C1OC(C(C2=CC3=C(OCO3)C=C2)=C1C4=CC=CC=C4)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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NPJ Acoust

Heterogeneous tumor blood oxygenation dynamics during phototherapy deciphered with real-time label-free photoacoustic imaging. [Abstract]

2025;1(1):9. PMID: 40485754

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Shin JS, et al. Potent anti-inflammatory effect of a novel furan-2,5-dione derivative, BPD, mediated by dual suppression of COX-2 activity and LPS-induced inflammatory gene expression via NF-κB inactivation. Br J Pharmacol. 2012 Mar;165(6):1926-1940. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- Essai clinique
Chemical Information
Publications (1)
Pureté et documentation
Références

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BPD

Publications Citing Use of MedChemExpress (MCE) BPD

Voir tous les produits spécifiques à Isoform COX

Voir tous les produits spécifiques à Isoform NF-κB