Cefroxadine
Cefroxadine (CGP 9000) is an orally active cephalosporin antibiotic. Cefroxadine is more effective than cephalexin against Escherichia coli and Klebsiella pneumoniae with MIC values of 3.13 and 1.56 μg/mL respectively with a concentration of 106 μg/mL. Cefroxadine can be used for the research of infection.
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- CAS No.: 51762-05-1
- Formule: C16H19N3O5S
- Masse moléculaire:365.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Activité biologique
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β-lactam |
Cefroxadine (106-108 μg/mL; overnight) shows antibacterial activities against S. aureus, E. coli, S. typhi, S. paratyphi, S. schottmuelleri, K. apneumoniae and P. mirabilis with MIC values of 1.56, 3.31, 1.56, 1.56, 1.56, 1.56 and 6.25 μg/mL respectively with a concentration of 106 μg/mL[1]. Cefroxadine (104-108 μg/mL; overnight) shows antibacterial activities against 100 E. coli strains with MIC50 and MIC75 values of 4.8-11.5 μg/mL and 6-20 μg/mL, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with E. coli ML4707 and K. pneumoniae GN6445 infection[1]
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Dosage:0-30 mg/kg
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Administration:Oral gavage; 0-30 mg/kg; 0 and 3 h after infection
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Result:Showed a better effect than cephalexin in vivo with ED50 values of 21.4 and 10.9 mg/kg for E. coli ML4707 and K. pneumoniae GN6445 in vivo.
Chemical Information
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CAS No. 51762-05-1
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Masse moléculaire 365.40
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Formule C16H19N3O5S
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SMILES
OC(C1=C(OC)CS[C@@]([C@@H]2NC([C@@H](C3=CCC=CC3)N)=O)([H])N1C2=O)=O
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Synonyms
CGP 9000; Oraspor
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cefroxadine Related Classifications
HY-107064 Related Classifications
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