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Cat. No.: HY-169378

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CSI86

CSI86 is a MYC-targeting PROTAC degrader with antiproliferative activity (IC₅₀: 13-18 μM).
(Pink: MYC ligand (HY-169379); Blue: VHL ligand (HY-120217); Black: linker (HY-79369)).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₄₈H₅₀F₉N₇O₇S
Masse moléculaire:1040.00

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CSI86 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

CSI86 is a MYC-targeting PROTAC degrader with antiproliferative activity (IC₅₀: 13-18 μM)^[1]. (Pink: MYC ligand (HY-169379); Blue: VHL ligand (HY-120217); Black: linker (HY-79369)).

Voir tous les produits spécifiques à Isoform PROTACs :

Chemical Information

Masse moléculaire 1040.00
Formule C₄₈H₅₀F₉N₇O₇S
SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCC(NCCCOC4=C(C(O)=C(C=C4)C5=CC(C(F)(F)F)=NN5C)C6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6)=O)=O)=O)O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Siokatas C, et al. Developing MYC Degraders Bearing the Von Hippel–Lindau Ligand to Target the “Undruggable” MYC[J]. ACS Pharmacology & Translational Science, 2024.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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CSI86

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CSI86 Related Classifications

HY-169378 Related Classifications