Eupolauridine
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases.
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- CAS No.: 58786-39-3
- Formule: C14H8N2
- Masse moléculaire:204.23
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Topoisomerase I |
Topoisomerase II |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
35.7 μM
Compound: 5
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Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
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[PMID: 21504145] |
| NCI-H460 | IC50 |
>100 μM
Compound: 5
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Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay
Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay
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[PMID: 21504145] |
| SK-OV-3 | IC50 |
>10 μg/mL
Compound: Eupo
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Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay
Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay
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[PMID: 27769668] |
| Vero | IC50 |
>10 μg/mL
Compound: Eupo
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Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red dye based assay
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[PMID: 27769668] |
Chemical Information
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CAS No. 58786-39-3
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Masse moléculaire 204.23
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Formule C14H8N2
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SMILES
C1(C2=CC=CC=C23)=NC=CC4=C1C3=NC=C4
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Synonyms
Canangine
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Khan SI, et al. Antifungal activity of eupolauridine and its action on DNA topoisomerases. Antimicrob Agents Chemother. 2002 Jun;46(6):1785-92. [Content Brief]
[2]. Lavanya M, et al. Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines. Top Curr Chem (Cham). 2021 Feb 24;379(2):13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eupolauridine Related Classifications
HY-N15319 Related Classifications
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