EIF4E2 - eukaryotic translation initiation factor 4E family member 2 Gene

Also Known as 4EHP; IF4e; 4E-LP; h4EHP; EIF4EL3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9470

About EIF4E2

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,550,689-232,583,644 (from NCBI)

This gene has 17 transcripts (splice variants), 250 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 16.4), colon (RPKM 13.5) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in positive regulation of miRNA mediated inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. Part of mRNA cap binding activity complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF4E2 Products (7)

mRNA Protein Name
NM_001276336.2 NP_001263265.1 eukaryotic translation initiation factor 4E type 2 isoform C
NM_001276337.2 NP_001263266.1 eukaryotic translation initiation factor 4E type 2 isoform D
NM_001282958.2 NP_001269887.1 eukaryotic translation initiation factor 4E type 2 isoform B
NM_001330201.2 NP_001317130.1 eukaryotic translation initiation factor 4E type 2 isoform E
NM_001330202.2 NP_001317131.1 eukaryotic translation initiation factor 4E type 2 isoform G
NM_001330203.2 NP_001317132.1 eukaryotic translation initiation factor 4E type 2 isoform F
NM_004846.4 NP_004837.1 eukaryotic translation initiation factor 4E type 2 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables RNA 7-methylguanosine cap binding IDA
IDA: Inferred from direct assay
35878012 GOA
enables mRNA cap binding IDA
IDA: Inferred from direct assay
17368478 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15094042 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
14623119 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of positive effect miRNA-mediated gene silencing by inhibition of translation IDA
IDA: Inferred from direct assay
28487484 GOA
acts upstream of or within negative regulation of translation IMP
IMP: Inferred from mutant phenotype
22751931 GOA
involved in negative regulation of translational initiation IDA
IDA: Inferred from direct assay
32726578 GOA
involved in negative regulation of type I interferon-mediated signaling pathway IDA
IDA: Inferred from direct assay
35878012 GOA
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
32726578 GOA
Cellular Component GO Annotation Evidence Références Source
located in P-body IDA
IDA: Inferred from direct assay
23991149 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
23991149 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4E2 Protein Structure

IF4E

IF4E: Eukaryotic initiation factor 4E (55 - 217)

  • 0
  • 100
  • 200
  • 245 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E type 2

  • eIF-4E type 2

EIF4E2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
EIF4E2 O60573 KRT13 Homo sapiens A1A4E9
Validated Y2H
25416956
Intra
EIF4E2 O60573 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
EIF4E2 O60573 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
EIF4E2 O60573 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
EIF4E2 O60573 HOMEZ Homo sapiens Q8IX15-3
Validated Y2H
25416956
Intra
EIF4E2 O60573 HOMEZ Homo sapiens Q8IX15-3
Y2H Array
25416956
Intra
EIF4E2 O60573 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
EIF4E2 O60573 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
Intra
EIF4E2 O60573 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra
EIF4E2 O60573 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
25416956
Intra
EIF4E2 O60573 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 CDR2 Homo sapiens Q01850
Validated Y2H
25416956
Intra
EIF4E2 O60573 CDR2 Homo sapiens Q01850
Y2H Array
25416956
Intra
EIF4E2 O60573 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 MIPOL1 Homo sapiens Q8TD10
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 EIF4ENIF1 Homo sapiens Q9NRA8
Anti Tag CoIP
33961781
Intra
EIF4E2 O60573 EIF4ENIF1 Homo sapiens Q9NRA8
Y2H Array
19060904
Intra
EIF4E2 O60573 EIF4ENIF1 Homo sapiens Q9NRA8
Anti Tag CoIP
28514442
Intra
EIF4E2 O60573 EIF4ENIF1 Homo sapiens Q9NRA8
Y2H Pooling
19060904
Intra
EIF4E2 O60573 EIF4ENIF1 Homo sapiens Q9NRA8
Y2H Pooling
16189514
Intra
EIF4E2 O60573 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
EIF4E2 O60573 MYOG Homo sapiens P15173
Y2H Array
31515488
Intra
EIF4E2 O60573 MYOG Homo sapiens P15173
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 MYOG Homo sapiens P15173
Validated Y2H
25416956
Intra
EIF4E2 O60573 MYOG Homo sapiens P15173
Y2H Array
25416956
Intra
EIF4E2 O60573 ZBTB9 Homo sapiens Q96C00
Y2H Array
31515488
Intra
EIF4E2 O60573 ZBTB9 Homo sapiens Q96C00
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 ZBTB9 Homo sapiens Q96C00
Validated Y2H
25416956
Intra
EIF4E2 O60573 ZBTB9 Homo sapiens Q96C00
Y2H Array
25416956
Intra
EIF4E2 O60573 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
25416956
Intra
EIF4E2 O60573 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 SPAG5 Homo sapiens Q96R06
Validated Y2H
25416956
Intra
EIF4E2 O60573 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
EIF4E2 O60573 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
EIF4E2 O60573 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
EIF4E2 O60573 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra
EIF4E2 O60573 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
EIF4E2 O60573 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
25416956
Intra
EIF4E2 O60573 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
EIF4E2 O60573 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
EIF4E2 O60573 MAPRE3 Homo sapiens Q9UPY8
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 EIF4EBP1 Homo sapiens Q13541
Anti Tag CoIP
33961781
Intra
EIF4E2 O60573 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 CBY2 Homo sapiens Q8NA61
Validated Y2H
25416956
Intra
EIF4E2 O60573 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 TADA2A Homo sapiens O75478
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 UBXN11 Homo sapiens Q5T124
Y2H Array
25416956
Intra
EIF4E2 O60573 CARD9 Homo sapiens Q9H257
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 USP54 Homo sapiens Q70EL1
Y2H Prey Pooling
25416956
Intra
EIF4E2 O60573 USP54 Homo sapiens Q70EL1
Validated Y2H
25416956
Intra
EIF4E2 O60573 USP54 Homo sapiens Q70EL1
Y2H Array
25416956
Intra
EIF4E2 O60573 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
EIF4E2 O60573 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Coffin-Siris Syndrome 2

  • CSS2

  • Mrd14

  • Mental Retardation, Autosomal Dominant 14

  • Autosomal Dominant Mental Retardation 14

  • Coffin-Siris Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04275 EIF4E2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EIF4E2 MGD MGI:1914440
Rattus norvegicus EIF4E2 RGD RGD:1307790
Bos taurus EIF4E2 VGNC VGNC:28410
Macaca mulatta EIF4E2 VGNC VGNC:72194
Others EIF4E2 NCBI