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Cat. No.: HY-119764

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Ikarugamycin

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.9%
CAS No.: 36531-78-9
Formule: C₂₉H₃₈N₂O₄
Masse moléculaire:478.62

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ikarugamycin Chemical Structure

CAS No.: 36531-78-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME)^[1].

IC₅₀ & Target

Clathrin-mediated endocytosis^[1]

Voir tous les produits spécifiques à Isoform Antibiotic :

In Vitro

Ikarugamycin has an IC₅₀ of 2.7 μM in H1299 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 36531-78-9
Appearance Solid
Masse moléculaire 478.62
Formule C₂₉H₃₈N₂O₄
Color White to light yellow
SMILES

O=C(/C=C/[C@@H]1C[C@]2([C@@]([H])([C@H]1C/C=C\3)C=C[C@@]4([C@@]2(C[C@H]([C@H]4CC)C)[H])[H])[H])C5=C([C@@H](NC5=O)CCCNC3=O)O
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces species
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

J Extracell Vesicles

Cdc42 functions as a regulatory node for tumour-derived microvesicle biogenesis. [Abstract]

2021 Jan;10(3):e12051. PMID: 33473262
J Immunother Cancer

Anticancer effects of ikarugamycin and astemizole identified in a screen for stimulators of cellular immune responses. [Abstract]

2023 Jul;11(7):e006785. PMID: 37419511

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Elkin SR, et al. Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis. Traffic. 2016 Oct;17(10):1139-49. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ikarugamycin

2 Cited Publications

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Chemical Information
Publications (2)
Pureté et documentation
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Ikarugamycin

Publications Citing Use of MedChemExpress (MCE) Ikarugamycin

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Publications (2)

Pureté et documentation

Références

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Help & FAQs

Ikarugamycin Related Classifications

HY-119764 Related Classifications