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Cat. No.: HY-120688

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L-772405

L-772405 is a selective 5-HT_1D receptor agonist with the K_i values of 318, 29 and ＞ 1000 nM aganist guinea pig 5-HT1_B receptor, guinea pig 5-HT_1D receptor and rat 5-HT rransporter, respectively. L-772405 decreases the potassium-induced outflow of 5-HT with an IC₅₀ value of 240 nM.

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CAS No.: 177947-03-4
Formule: C₂₆H₃₁FN₆O
Masse moléculaire:462.56

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

L-772405 Chemical Structure

CAS No.: 177947-03-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

5-HT_1B Receptor

5-HT_1D Receptor

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.8 nM Compound: 80	Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor	[PMID: 10585208]
CHO	IC₅₀	>10000 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1F receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1F receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	>10000 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 5A receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 5A receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	>10000 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 6 receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 6 receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	0.9 nM Compound: 80	Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells Displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	1100 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 2A receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	150 nM Compound: 80	Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells Displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	540 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	66 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1A receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1A receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	IC₅₀	>10000 nM Compound: 80	Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1E receptor stably expressed in CHO cells Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1E receptor stably expressed in CHO cells	[PMID: 10585208]
CHO	EC₅₀	1.1 nM Compound: 6h	Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor. Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.	[PMID: 9357514]
CHO	IC₅₀	0.9 nM Compound: 6h	Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement. Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.	[PMID: 9357514]
CHO	IC₅₀	185 nM Compound: 6h	Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement. Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.	[PMID: 9357514]
CHO	EC₅₀	1.1 nM Compound: 1	Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptor	[PMID: 9667955]
CHO	IC₅₀	0.9 nM Compound: 1	Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells	[PMID: 9667955]

Chemical Information

CAS No. 177947-03-4
Masse moléculaire 462.56
Formule C₂₆H₃₁FN₆O
SMILES

OC[C@@H](C1=CC=C(C=C1)F)NC(CC2)CCN2CCCC3=CNC4=CC=C(N5C=NN=C5)C=C34
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pullar IA, et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur J Pharmacol. 2004 Jun 16;493(1-3):85-93. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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L-772405

Voir tous les produits spécifiques à Isoform 5-HT Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

L-772405 Related Classifications

HY-120688 Related Classifications