Lerimazoline
Lerimazoline is a selective 5-HT1D receptor agonist with Ki values of 72 and 3480 nM for h5-HT1D and h5-HT1B. Lerimazoline inhibits Forskolin (HY-15371)-stimulated cAMP production and induces contractions in rabbit saphenous vein preparations. Lerimazoline can be used for the research of migraine.
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- CAS No.: 54765-26-3
- Formule: C13H18N2
- Masse moléculaire:202.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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5-HT1D Receptor 72 nM (Ki) |
5-HT1B Receptor 3480 nM (Ki) |
Lerimazoline (Compound 29) (0.1-1 μM; 60 min) binds to human h5-HT1B receptors with a Ki of 3480 nM[1].
Lerimazoline (0.1-1 μM; 60 min) binds to human h5-HT1D receptors with a Ki of 72 nM, displaying 48-fold selectivity for h5-HT1D over h5-HT1B receptors[1].
Lerimazoline (1-10 μM; 30 min) inhibits Forskolin (HY-15371)-stimulated cAMP production in transfected CHO Pro 5 cells[1].
Lerimazoline (10-10000 nM) induces contractions of rabbit saphenous vein with a 95% of the maximal effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 54765-26-3
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Masse moléculaire 202.30
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Formule C13H18N2
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SMILES
CC1=C(CC2=NCCN2)C(C)=CC(C)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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