Cat. No.: HY-N0648

Monotropein

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model. Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin (HY-17394)-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-κB signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury.

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Pureté: 99.80%
CAS No.: 5945-50-6
Formule: C₁₆H₂₂O₁₁
Masse moléculaire:390.34

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Monotropein Chemical Structure

CAS No.: 5945-50-6

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Interleukin Related :

Voir tous les produits spécifiques à Isoform Heme Oxygenase (HO) :

HO-1
HO-2

Voir tous les produits spécifiques à Isoform NF-κB :

In Vitro

Monotropein (100 μg/mL, 24 h) decreases the apoptotic rate of chondrocytes^[1].
Monotropein (25-100 μg/mL, 24 h) significantly decreases the mRNA levels of MMP-3 and MMP-13 in chondrocytes^[1].
Monotropein (25-100 μg/mL, 48 h) exhibits anti-apoptosis and anti-catabolic activity and counteracts the effect of IL-1β^[1].
Monotropein (Compound Mon) (0-200 μg/mL, 24 h) enhances cell viability and reduces apoptosis in LPS-treated MLE-12 cells^[3].
Monotropein (12.5-100 μg/mL, 24 h) reduces inflammatory response and fibrosis induced by LPS in MLE-12 cells^[3].
Monotropein (100 μg/mL, 24 h) inhibits NF-κB pathway in LPS-elicited MLE-12 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:

LPS-elicited MLE-12 cells
Concentration:

100 μg/mL
Incubation Time:

24 h
Result:

Decreased the concentrations of TNF-α, IL-1β, and IL-6.
Decreased relative protein expression of -SMA, FN, and Collagen I.

In Vivo

Monotropein (25-100 mg/kg, i.g., single dose) greatly reduces the content of IL-1β, TNF-α, and PGE₂ in rat model with knee OA SF lavages^[1].
Monotropein (100 mg/kg, i.g., single dose) exhibits chondroprotective effects on knee joint tissue of OA rat model^[1].
Monotropein (20 mg/kg, i.p., 1 h pre-treatment and 24-48 h after) attenuates cisplatin-induced renal dysfunction and histopathological damage in AKI mouse model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

AKI BALB/c mouse model (20-25 g) injected (i.p.) with 20 mg/kg Cisplatin^[2]
Dosage:

20 mg/kg
Administration:

Intraperitoneal injection (i.p.), 1 h pre-treatment and 24-48 h after
Result:

Reduced the level on BUN compared to control group.
Attenuated cisplatin-induced oxidative stress in kidney.
Attenuated inflammation in kidney.
Reversed the anti-apoptotic protein Bcl-2 and pro-apoptotic proteins including Bax.

Chemical Information

CAS No. 5945-50-6
Appearance Solid
Masse moléculaire 390.34
Formule C₁₆H₂₂O₁₁
Color Off-white to yellow
SMILES

O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@@]3(O)CO)([H])[C@@](C=C3)([H])C(C(O)=O)=CO2
Structure Classification
- Terpenoids
- Iridoids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Int Immunopharmacol

The active ingredient Monotropein in Morinda officinalis alleviates neuroinflammation via inhibiting cGAS/STING signaling pathway. [Abstract]

2026 Aug 15:183:116862. PMID: 42150287
Viruses

Anthraquinone-2-Carboxylic Acid Is a Potential Antiviral Candidate Against Influenza Viruses In Vitro and In Vivo. [Abstract]

2025 Apr 27;17(5):628. PMID: 40431640
SSRN

2026 Mar 3.

Solvant et solubilité

In Vitro:

H₂O : 31.25 mg/mL (80.06 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5619 mL

12.8093 mL

25.6187 mL

5 mM

0.5124 mL

2.5619 mL

5.1237 mL

10 mM

0.2562 mL

1.2809 mL

2.5619 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (286 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang F, et al.Monotropein exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes.Int Immunopharmacol. 2014 Dec;23(2):575-80. [Content Brief]

[2]. Zhang, Y., et al., (2020). The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 129, 110408. [Content Brief]

[3]. Gong, Y., & Wang, J. (2023). Monotropein alleviates sepsis-elicited acute lung injury via the NF-κB pathway. The Journal of pharmacy and pharmacology, 75(9), 1249–1258. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.5619 mL	12.8093 mL	25.6187 mL	64.0467 mL
	5 mM	0.5124 mL	2.5619 mL	5.1237 mL	12.8093 mL
	10 mM	0.2562 mL	1.2809 mL	2.5619 mL	6.4047 mL
	15 mM	0.1708 mL	0.8540 mL	1.7079 mL	4.2698 mL
	20 mM	0.1281 mL	0.6405 mL	1.2809 mL	3.2023 mL
	25 mM	0.1025 mL	0.5124 mL	1.0247 mL	2.5619 mL
	30 mM	0.0854 mL	0.4270 mL	0.8540 mL	2.1349 mL
	40 mM	0.0640 mL	0.3202 mL	0.6405 mL	1.6012 mL
	50 mM	0.0512 mL	0.2562 mL	0.5124 mL	1.2809 mL
	60 mM	0.0427 mL	0.2135 mL	0.4270 mL	1.0674 mL
	80 mM	0.0320 mL	0.1601 mL	0.3202 mL	0.8006 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Monotropein

3 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Monotropein

Voir tous les produits spécifiques à Isoform Interleukin Related

Voir tous les produits spécifiques à Isoform Heme Oxygenase (HO)

Voir tous les produits spécifiques à Isoform NF-κB

Activité biologique

Chemical Information

Publications (3)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Monotropein Related Classifications

HY-N0648 Related Classifications