Cat. No.: HY-E70250

Neocryptolepine

(Synonyms: Cryptotackieine)

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Neocryptolepine (Cryptotackieine) has antiplasmodial activity. Neocryptolepine also shows antibacterial activity against Gram-positive bacteria (MIC < 100 μg/mL), and antifungal activity.

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Pureté: 98.05%
CAS No.: 114414-78-7
Formule: C₁₆H₁₂N₂
Masse moléculaire:232.28

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Neocryptolepine Chemical Structure

CAS No.: 114414-78-7

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Neocryptolepine (Cryptotackieine) has antiplasmodial activity. Neocryptolepine also shows antibacterial activity against Gram-positive bacteria (MIC < 100 μg/mL), and antifungal activity^[1]^[2].

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Cellular Effect

Cell Line	Type	Value	Description	References
Ehrlich	IC₅₀	0.54 nM Compound: 15	Cytotoxicity against mouse Ehrlich cells assessed as cell growth inhibition incubated for 3 hrs by trypan blue exclusion assay Cytotoxicity against mouse Ehrlich cells assessed as cell growth inhibition incubated for 3 hrs by trypan blue exclusion assay	[PMID: 34710743]
Ehrlich	IC₅₀	5.4 x 10^-4 μM Compound: 15	Cytotoxicity against mouse Ehrlich cells assessed as cell growth inhibition incubated for 3 hrs by trypan blue exclusion assay Cytotoxicity against mouse Ehrlich cells assessed as cell growth inhibition incubated for 3 hrs by trypan blue exclusion assay	[PMID: 34710743]
L6	IC₅₀	3194 nM Compound: Neocryptolepine	Toxicity against rat L6 cells after 72 hrs by Alamar blue assay Toxicity against rat L6 cells after 72 hrs by Alamar blue assay	[PMID: 23360309]
L6	IC₅₀	3194 nM Compound: II, cryptotackieine, Neocryptolepine	Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar blue staining-based inverted microscopic analysis Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar blue staining-based inverted microscopic analysis	[PMID: 23685569]
L6	IC₅₀	3.19 μM Compound: 15	Cytotoxicity against rat L6 cells assessed as cell growth inhibition Cytotoxicity against rat L6 cells assessed as cell growth inhibition	[PMID: 34710743]
MRC5	IC₅₀	11 μM Compound: 1a	Cytotoxicity against human diploid embryonic lung cell line MRC-5 using MTT assay Cytotoxicity against human diploid embryonic lung cell line MRC-5 using MTT assay	[PMID: 12139461]
MRC5	IC₅₀	11 μM Compound: 3, (Neocryptolepine, Cryptotackieine)	Cytotoxicity against human MRC5 SV2 cells after 72 hrs by resazurin-based fluorometric assay Cytotoxicity against human MRC5 SV2 cells after 72 hrs by resazurin-based fluorometric assay	[PMID: 19364118]
MRC5	IC₅₀	11 μM Compound: 15	Antiproliferative activity against human MRC5 cells assessed as cell growth inhibition incubated for 7 days by MTT assay Antiproliferative activity against human MRC5 cells assessed as cell growth inhibition incubated for 7 days by MTT assay	[PMID: 34710743]
MRC5	IC₅₀	11 μM Compound: 15	Cytotoxicity against human MRC5 cells assessed as cell growth inhibition Cytotoxicity against human MRC5 cells assessed as cell growth inhibition	[PMID: 34710743]

Chemical Information

CAS No. 114414-78-7
Appearance Solid
Masse moléculaire 232.28
Formule C₁₆H₁₂N₂
Color Yellow to orange
SMILES

CN1C2=C(C=CC=C2)C=C3C4=C(C=CC=C4)N=C13
Synonyms

Cryptotackieine
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvant et solubilité

In Vitro:

DMSO : ≥ 100 mg/mL (430.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.3051 mL

21.5257 mL

43.0515 mL

5 mM

0.8610 mL

4.3051 mL

8.6103 mL

10 mM

0.4305 mL

2.1526 mL

4.3051 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pilar M. Fresneda, et al. A divergent approach to cryptotackieine and cryptosanguinolentine alkaloids.

[2]. Cimanga K, et al. Antibacterial and antifungal activities of neocryptolepine, biscryptolepine and cryptoquindoline, alkaloids isolated from Cryptolepis sanguinolenta. Phytomedicine. 1998 May;5(3):209-14. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.3051 mL	21.5257 mL	43.0515 mL	107.6287 mL
	5 mM	0.8610 mL	4.3051 mL	8.6103 mL	21.5257 mL
	10 mM	0.4305 mL	2.1526 mL	4.3051 mL	10.7629 mL
	15 mM	0.2870 mL	1.4350 mL	2.8701 mL	7.1752 mL
	20 mM	0.2153 mL	1.0763 mL	2.1526 mL	5.3814 mL
	25 mM	0.1722 mL	0.8610 mL	1.7221 mL	4.3051 mL
	30 mM	0.1435 mL	0.7175 mL	1.4350 mL	3.5876 mL
	40 mM	0.1076 mL	0.5381 mL	1.0763 mL	2.6907 mL
	50 mM	0.0861 mL	0.4305 mL	0.8610 mL	2.1526 mL
	60 mM	0.0718 mL	0.3588 mL	0.7175 mL	1.7938 mL
	80 mM	0.0538 mL	0.2691 mL	0.5381 mL	1.3454 mL
	100 mM	0.0431 mL	0.2153 mL	0.4305 mL	1.0763 mL

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Neocryptolepine

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Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Neocryptolepine

Anti-Infection Compound Library

Natural Product Library

Antifungal Compound Library

Antibacterial Compound Library

Alkaloids Library

Antiparasitic Compound library

Plant-Sourced Natural Product Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Neocryptolepine Related Classifications

HY-E70250 Related Classifications