NTZ-24
NTZ-24 is a selective STAT3 pathway inhibitor. NTZ-24 suppresses STAT3 phosphorylation at Tyr705, blocks STAT3-DNA interaction, and downregulates the levels of STAT3 downstream target proteins. NTZ-24 induces cell-cycle arrest and promotes apoptosis in cancer cells. NTZ-24 exerts significant antiproliferative activity against HeLa cells (IC50 = 3.3 μM). NTZ-24 can be used for the research of cervical cancer.
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- CAS No.: 69819-42-7
- Formule: C10H5Cl2N3O3S
- Masse moléculaire:318.14
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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STAT3 0.8 μM (IC50) |
IL-6 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
3.3 μM
Compound: 24
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Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
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[PMID: 34055214] |
NTZ-24 (compound 24) inhibits the IL-6/JAK/STAT3 pathway in HEK-Blue IL-6 cells with an IC50 of 0.8 μM[1].
NTZ-24 (48 h) inhibits the proliferation of HeLa epithelial carcinoma cells with an IC50 of 3.3 μM[1].
NTZ-24 (10-50 μM; 48 h) exhibits low cytotoxicity in human normal embryonic kidney HEK 293T cells, with 8.0% and 19.1% cell viability inhibition at 10 μM and 50 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 69819-42-7
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Masse moléculaire 318.14
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Formule C10H5Cl2N3O3S
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SMILES
O=C(C1=CC=C(C(Cl)=C1)Cl)NC2=NC=C([N+]([O-])=O)S2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NTZ-24 Related Classifications
HY-182510 Related Classifications
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