Oncaspar
Based on 1 Customer Validation
Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) through asparagine hydrolysis and activation of the integrated stress response (ISR) pathway.
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- Pureté: 99.9%
- CAS No.: 130167-69-0
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Oncaspar (2 IU/mL, 48 h) inhibits the cell viability of 266-6, suppresses the expression of ATF3/4 proteins, and promotes the expression of FGF21 protein[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:266-6
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Concentration:2 IU/mL
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Incubation Time:48 h
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Result:Inhibited the cell viability.
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Cell Line:266-6
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Concentration:2 IU/mL
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Incubation Time:48 h
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Result:Downregulated the expression of ATF3 proteins, upregulated the expression of FGF21 protein.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats models[2]
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Dosage:1 IU/g
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Administration:intramuscular, single dose
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Result:Increased plasma lipase levels, inhibited the weight gain of rats, increased the levels of inflammatory markers IL6 and IL1β in pancreatic tissue, caused edema and inflammatory infiltration in the pancreases of rats.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Conjugated with pegol
The product can be reconstituted/diluted with sterile PBS or saline.
Chemical Information
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CAS No. 130167-69-0
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Oncaspar]
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Synonyms
PEG-L-asparaginase; Pegasparaginase
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
[1]. Young-A Heo, et al. Pegaspargase: A Review in Acute Lymphoblastic Leukaemia.Drugs. 2019 May;79(7):767-777. [Content Brief]
[2]. He J, et al., Insufficient secretion of pancreatic FGF21 is the toxicological mechanism and therapeutic target of asparaginase-associated pancreatitis. Toxicol Appl Pharmacol. 2024 Apr;485:116920. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oncaspar Related Classifications
HY-108860 Related Classifications
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