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Cat. No.: HY-19137

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Pibrozelesin

Name: Pibrozelesin
Brand: MedChemExpress
SKU: HY-19137
Availability: PreOrder

(Synonyms: KW 2189 free base)

Pibrozelesin (KW 2189 free base) is the derivative of antibiotic Duocarmycin B2. Pibrozelesin exhibits antitumor activity, inhibits proliferation of cell H69 with an IC₅₀ of 1.9 μM. Pibrozelesin induces the DNA strand breaks upon activation via carboxyl esterase.

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CAS No.: 154889-68-6
Formule: C₃₂H₃₆BrN₅O₈
Masse moléculaire:698.56

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Pibrozelesin Chemical Structure

CAS No.: 154889-68-6

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Antibiotic :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	18.1 ng/mL Compound: 7	Concentration required to inhibit the growth of HeLaS3 human uterine cervix carcinoma cells by 50% Concentration required to inhibit the growth of HeLaS3 human uterine cervix carcinoma cells by 50%	[PMID: 10212131]
HeLa	IC₅₀	18.1 ng/mL Compound: 7	Concentration required for 50% inhibition of human uterine Cervix Carcinoma cells (HeLaS3) Concentration required for 50% inhibition of human uterine Cervix Carcinoma cells (HeLaS3)	10.1016/S0960-894X(97)00288-6

Chemical Information

CAS No. 154889-68-6
Masse moléculaire 698.56
Formule C₃₂H₃₆BrN₅O₈
SMILES

BrC[C@H]1C2=C(N(C1)C(C(NC3=C4OC)=CC3=CC(OC)=C4OC)=O)C=C(OC(N5CCN(CC5)C)=O)C6=C2C(C(OC)=O)=C(C)N6
Synonyms

KW 2189 free base
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ogasawara H, et al., A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells. Jpn J Cancer Res. 1994 Apr;85(4):418-25. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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