Rudolfomycin
Rudolfomycin is an anthracycline Antibiotic, composed of the aglycone ε-pyrromycinone and three glycosyl sugar units. Rudolfomycin inhibits the growth of mammalian tumors and exhibits antibacterial activity against Gram-positive bacteria. Rudolfomycin can be used in the research of leukemia and Gram-positive bacterial infections.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 69245-38-1
- Formule: C42H52N2O16
- Masse moléculaire:840.87
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Antibiotic
More
Activité biologique
Rudolfomycin (0.25-8 μg/mL) potently inhibits the growth of gram-positive bacteria including Streptococcus pneumoniae A-9585 (MIC 0.25 μg/mL), Streptococcus pyogenes A-9604 (MIC 0.5 μg/mL), Staphylococcus aureus A-9537 (MIC 2 μg/mL), Staphylococcus aureus A-9606 (MIC 8 μg/mL), and Streptococcus faecalis A-20688 (MIC 4 μg/mL), but is inactive against gram-negative bacteria and most tested fungi[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BDF1 mice (female; implanted i.p. with 106 L-1210 leukemia ascites cells)[1]
-
Dosage:12.8, 6.4, 3.2, 1.6, 0.8, 0.4 mg/kg
6.4, 3.2, 1.6, 0.8, 0.4, 0.2 mg/kg
3.2, 1.6, 0.8, 0.4, 0.2, 0.1 mg/kg
1.6, 0.8, 0.4, 0.2, 0.1, 0.05 mg/kg -
Administration:i.p.; single dose
i.p.; days 1, 4, 7
i.p.; daily, 5 days
i.p.; daily, 9 days -
Result:Attained the peak median survival time (MST) of 10.0 days and maximal % T/C value of 143 across single intraperitoneal (i.p.) bolus, intermittent day 1/4/7 i.p., 5-day daily i.p. and 9-day daily i.p. schedules at corresponding medium dose groups.
Attained a secondary MST of 9.5 days with a % T/C of 136 only in the day 1/4/7 intermittent i.p. group treated with 0.8 mg/kg.
Attained a consistent MST of 9.0 days and % T/C of 129 at multiple dosages covering all four administration modes.
Attained a uniform MST of 8.0 days and % T/C of 114 across low-dose cohorts of all four dosing regimens.
Attained a moderate MST of 7.5 days with a % T/C of 107 in the 9-day daily i.p. group at 1.6 and 0.1 mg/kg.
Attained the lowest MST of 7.0 days with a % T/C of 100 under day 1/4/7 intermittent i.p. administration at 3.2 mg/kg.
Chemical Information
-
CAS No. 69245-38-1
-
Masse moléculaire 840.87
-
Formule C42H52N2O16
-
SMILES
O=C(C1[C@@](O)(CC)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4C(N)=CC([C@@H](C)O4)=O)[C@H](C)O3)[C@H](C)O2)C5=C(O)C6=C(C(C7=C(O)C=CC(O)=C7C6=O)=O)C=C15)OC
-
Structure Classification
-
Initial Source
Actinosporangium species ATCC 31127
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rudolfomycin Related Classifications
HY-126731 Related Classifications
Powered by Bioz