Cat. No.: HY-N0121

Sesamin

12 Cited Publications

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Based on 12 publication(s) in Google Scholar

Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia.

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Pureté: 99.85%
CAS No.: 607-80-7
Formule: C₂₀H₁₈O₆
Masse moléculaire:354.35

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Sesamin Chemical Structure

CAS No.: 607-80-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (12)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

delta 5 desaturase^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Daoy	ED₅₀	>20 μg/mL Compound: 14	Cytotoxicity against human DaOY cells after 3 days by MTT assay Cytotoxicity against human DaOY cells after 3 days by MTT assay	[PMID: 21115251]
HeLa	ED₅₀	>20 μg/mL Compound: 14	Cytotoxicity against human HeLa cells after 3 days by MTT assay Cytotoxicity against human HeLa cells after 3 days by MTT assay	[PMID: 21115251]
HEp-2	ED₅₀	>20 μg/mL Compound: 14	Cytotoxicity against human Hep2 cells after 3 days by MTT assay Cytotoxicity against human Hep2 cells after 3 days by MTT assay	[PMID: 21115251]
HepG2	EC₅₀	>60 μM Compound: 4	Transactivation of PPAR expressed in HepG2 cells after 20 hrs by luminescence assay Transactivation of PPAR expressed in HepG2 cells after 20 hrs by luminescence assay	[PMID: 22381047]
HepG2	IC₅₀	229 μM Compound: Sesamin	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 31784199]
HepG2	IC₅₀	9.4 μM Compound: 4	Inhibition of TNFalpha-induced NFkappaB transcriptional activity in human HepG2 cells pretreated for 1 hr before TNFalpha challenge by luciferase reporter gene analysis Inhibition of TNFalpha-induced NFkappaB transcriptional activity in human HepG2 cells pretreated for 1 hr before TNFalpha challenge by luciferase reporter gene analysis	[PMID: 22381047]
KB	ED₅₀	>100 μg/mL Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 521819]
MCF7	ED₅₀	>20 μg/mL Compound: 14	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 21115251]
Neutrophil	IC₅₀	1.38 μg/mL Compound: (+)-Episesamin	Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced elastase release Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced elastase release	[PMID: 19128011]
Neutrophil	IC₅₀	4.3 μg/mL Compound: (+)-Episesamin	Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation Antiinflammatory activity against human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation	[PMID: 19128011]
Neutrophil	IC₅₀	90.23 μM Compound: 7, (-)-sesamin	Inhibition of fMLP-induced superoxide production in human neutrophils Inhibition of fMLP-induced superoxide production in human neutrophils	[PMID: 17559265]
SH-SY5Y	IC₅₀	229 μM Compound: Sesamin	Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 31784199]

In Vitro

Pretreated with sesamin, Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sesamin (o.p.; 20 mg/kg/day) significantly reduces the infarct size by approximately 50% in male gerbils (60-85 g)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 607-80-7
Appearance Solid
Masse moléculaire 354.35
Formule C₂₀H₁₈O₆
Color White to off-white
SMILES

[H][C@@]12[C@@H](C3=CC=C(OCO4)C4=C3)OC[C@]1([H])[C@@H](C5=CC=C(OCO6)C6=C5)OC2
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (12)

All Cell Proliferation/Viability AssayApoptosis AnalysisWBFlow CytometryIn Vivo Efficacy Study

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Journal Impact Factor

Phytomedicine

Sesamin ameliorates high-fat diet-induced inflammation and metabolic dysfunction in pregnant uterine smooth muscle via cGAS-STING inhibition. [Abstract]

2026 Jul:156:158182. PMID: 42025545
Phytomedicine

Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation. [Abstract]

2025 May:140:156484. PMID: 40090046
Int J Biol Macromol

Natural angiotensin II type 1 receptor inhibitors: Virtual screening and in vitro evaluation of beta-1,2,3,4,6-penta-O-galloyl-d-glucopyranose, icarrin, and sesamin for osteoarthritis therapy. [Abstract]

2025 Mar 25:142184. PMID: 40147655
Chin Med

Identification of anti-fibrotic compounds from Piper longum L via hollow fiber cell fishing and high-performance liquid chromatography with in vivo and in vitro validation. [Abstract]

2025 Aug 19;20(1):127. PMID: 40830877
Pestic Biochem Physiol

Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5/FOXO3a signaling pathway. [Abstract]

2026 Jan;216(Pt 1):106728. PMID: 41326063
Cell Signal

Expression and functional activity of myosin II in hyperplastic prostates of varying volumes. [Abstract]

2023 Jun:106:110658. PMID: 36935086
Front Biosci (Landmark Ed)

Sesamin Exerts Anti-Tumor Activity in Nasopharyngeal Carcinoma Through Inducing Autophagy and Reactive Oxygen Species Production. [Abstract]

2025 Apr 25;30(4):26038. PMID: 40302321
J Funct Foods

2026 Feb 20.
J Orthop Surg Res

The mechanism by which Naru 3 pill protects against intervertebral disc cartilage endplate degeneration based on network pharmacology and experimental verification. [Abstract]

2023 Jul 31;18(1):552. PMID: 37525208

Sesamin purchased from MedChemExpress. Usage Cited in: J Orthop Surg Res. 2023 Jul 31;18(1):552. [Abstract]

Sesamin (1, 4, 7 μM) treatment delayed LPS-induced apoptosis in ATDC5 cells.

Sesamin purchased from MedChemExpress. Usage Cited in: J Orthop Surg Res. 2023 Jul 31;18(1):552. [Abstract]

Sesamin (1, 4, 7 μM) treatment promoted LPS-induced proliferation in ATDC5 cells and decreased the rate of EdU-positive cells by flow cytometry.
J Cosmet Dermatol

Sesamin attenuates UVA-induced keratinocyte injury via inhibiting ASK-1-JNK/p38 MAPK pathways. [Abstract]

2024 Jan;23(1):316-325. PMID: 37545137
Chem Biol Drug Des

Sesamin exerts anti-tumor activity in esophageal squamous cell carcinoma via inhibition of TRIM44 and NF-κB signaling. [Abstract]

2022 Jan;99(1):118-125. PMID: 34411455

Sesamin purchased from MedChemExpress. Usage Cited in: Chem Biol Drug Des. 2022 Jan;99(1):118-125. [Abstract]

Four ESCC cell lines were incubated with indicated concentrations of Sesamin overnight, and subjected to CCK-8 assay.

Sesamin purchased from MedChemExpress. Usage Cited in: Chem Biol Drug Des. 2022 Jan;99(1):118-125. [Abstract]

ECA109 and KYSE150 cells were incubated with Sesamin (0, 10, 20, 40 μM) overnight, and the protein levels of TRIM44 and TLR4 were determined by Western blot assay.

Sesamin purchased from MedChemExpress. Usage Cited in: Chem Biol Drug Des. 2022 Jan;99(1):118-125. [Abstract]

Tumor volumes were significantly decreased in Sesamin (100, 150 mg/kg, p.o.) treated groups.
Neuropsychiatr Dis Treat

4-Hydroxysesamin, a Modified Natural Compound, Attenuates Neuronal Apoptosis After Ischemic Stroke via Inhibiting MAPK Pathway. [Abstract]

2024 Mar 7:20:523-533. PMID: 38469210

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (282.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8221 mL

14.1103 mL

28.2207 mL

5 mM

0.5644 mL

2.8221 mL

5.6441 mL

10 mM

0.2822 mL

1.4110 mL

2.8221 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cheng FC, et al. Neuroprotective effects of sesamin and sesamolin on gerbil brain in cerebral ischemia. Int J Biomed Sci. 2006 Sep;2(3):284-8. [Content Brief]

[2]. Shimizu S, et al. Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acidbiosynthesis. Lipids. 1991 Jul;26(7):512-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8221 mL	14.1103 mL	28.2207 mL	70.5517 mL
	5 mM	0.5644 mL	2.8221 mL	5.6441 mL	14.1103 mL
	10 mM	0.2822 mL	1.4110 mL	2.8221 mL	7.0552 mL
	15 mM	0.1881 mL	0.9407 mL	1.8814 mL	4.7034 mL
	20 mM	0.1411 mL	0.7055 mL	1.4110 mL	3.5276 mL
	25 mM	0.1129 mL	0.5644 mL	1.1288 mL	2.8221 mL
	30 mM	0.0941 mL	0.4703 mL	0.9407 mL	2.3517 mL
	40 mM	0.0706 mL	0.3528 mL	0.7055 mL	1.7638 mL
	50 mM	0.0564 mL	0.2822 mL	0.5644 mL	1.4110 mL
	60 mM	0.0470 mL	0.2352 mL	0.4703 mL	1.1759 mL
	80 mM	0.0353 mL	0.1764 mL	0.3528 mL	0.8819 mL
	100 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.7055 mL

Keywords

Sesamin

12 Cited Publications

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Sesamin

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Publications Citing Use of MedChemExpress (MCE) Sesamin

Activité biologique

Chemical Information

Publications (12)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Sesamin Related Classifications

HY-N0121 Related Classifications