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Cat. No.: HY-100702

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SH-5

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Based on 1 publication(s) in Google Scholar

SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke.

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CAS No.: 701976-54-7
Formule: C₂₉H₅₉O₁₀P
Masse moléculaire:598.75

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

SH-5 Chemical Structure

CAS No.: 701976-54-7

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Akt :

Cellular Effect

Cell Line	Type	Value	Description	References
184B5	GI₅₀	10.35 μM Compound: 2	Cytotoxicity against human 184B5 cells at 10 uM chloroquine by SRB assay Cytotoxicity against human 184B5 cells at 10 uM chloroquine by SRB assay	[PMID: 18691894]
184B5	GI₅₀	13.76 μM Compound: 2	Cytotoxicity against human 184B5 cells by SRB assay Cytotoxicity against human 184B5 cells by SRB assay	[PMID: 18691894]
184B5	GI₅₀	8.98 μM Compound: 2	Cytotoxicity against human 184B5 cells at 20 uM chloroquine by SRB assay Cytotoxicity against human 184B5 cells at 20 uM chloroquine by SRB assay	[PMID: 18691894]
MCF7	GI₅₀	15.64 μM Compound: 2	Cytotoxicity against human MCF7 cells in presence of 10 uM chloroquine by SRB assay Cytotoxicity against human MCF7 cells in presence of 10 uM chloroquine by SRB assay	[PMID: 18691894]
MCF7	GI₅₀	16.01 μM Compound: 2	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 18691894]
MCF7	GI₅₀	7.94 μM Compound: 2	Cytotoxicity against human MCF7 cells in presence of 20 uM chloroquine by SRB assay Cytotoxicity against human MCF7 cells in presence of 20 uM chloroquine by SRB assay	[PMID: 18691894]
MDA-MB-231	GI₅₀	14.67 μM Compound: 2	Cytotoxicity against human MDA-MB-231 cells in presence of 10 uM chloroquine by SRB assay Cytotoxicity against human MDA-MB-231 cells in presence of 10 uM chloroquine by SRB assay	[PMID: 18691894]
MDA-MB-231	GI₅₀	16.77 μM Compound: 2	Cytotoxicity against human MDA-MB-231 cells by SRB assay Cytotoxicity against human MDA-MB-231 cells by SRB assay	[PMID: 18691894]
MDA-MB-231	GI₅₀	9.39 μM Compound: 2	Cytotoxicity against human MDA-MB-231 cells in presence of 20 uM chloroquine by SRB assay Cytotoxicity against human MDA-MB-231 cells in presence of 20 uM chloroquine by SRB assay	[PMID: 18691894]
MDA-MB-468	GI₅₀	0.06 μM Compound: 2	Cytotoxicity against human MDA-MB-468 cells in presence of 20 uM chloroquine by SRB assay Cytotoxicity against human MDA-MB-468 cells in presence of 20 uM chloroquine by SRB assay	[PMID: 18691894]
MDA-MB-468	GI₅₀	19.26 μM Compound: 2	Cytotoxicity against human MDA-MB-468 cells in presence of 10 uM chloroquine by SRB assay Cytotoxicity against human MDA-MB-468 cells in presence of 10 uM chloroquine by SRB assay	[PMID: 18691894]
MDA-MB-468	GI₅₀	28.43 μM Compound: 2	Cytotoxicity against human MDA-MB-468 cells by SRB assay Cytotoxicity against human MDA-MB-468 cells by SRB assay	[PMID: 18691894]

In Vitro

SH-5 (5 µM; 4+24 h) increases the cytotoxicity with 1 nM TNF in H1299 cells^[1].
SH-5 (5 µM; 4+0, 6, 12, 18, 24 h) potentiates the apoptosis induced by tumor necrosis factor (TNF) in H1299 cells^[1].
SH-5 (1, 3, 5 µM) inhibits TNF (1 nM; 24 h)-induced COX-2 gene expression in a dose-dependent manner^[1]. SH-5 (5 µM; 4+0, 6, 12, 18, 24 h) decreases the protein expression of 1 nM TNF-induced IAP-1, XIAP, Bcl-Xl, Bcl-2, TRAF1, Survivin, COX-2, Cyclin D1, MMP-9 in a time-dependent manner in KBM-5 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

H1299 cells
Concentration:

5 µM
Incubation Time:

4+0, 6, 12, 18, 24 h
Result:

Increased the protein expression of Cleaved-PARP in a time-dependent manner.

Chemical Information

CAS No. 701976-54-7
Masse moléculaire 598.75
Formule C₂₉H₅₉O₁₀P
SMILES

CCCCCCCCCCCCCCCCCCOC[C@@H](OC)COP(O[C@@H]1[C@@H](C[C@H]([C@@H]([C@H]1O)O)O)OC)(O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Dent Sci

2025 Nov 1.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76(11):1404-16. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Publications (1)
Pureté et documentation
Références

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SH-5

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