VU6001376
VU6001376 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4 PAM) with an EC50 of 50.1 nM.
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- CAS No.: 1968546-34-0
- Formule: C18H14F2N6OS
- Masse moléculaire:400.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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mGlu4 50.1 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
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| CHO | EC50 |
50.1 nM
Compound: 27o; VU6001376
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Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mobilization preincubated for 142 secs followed by EC20 glutamate addition and subsequent EC80 glutamate add
Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mobilization preincubated for 142 secs followed by EC20 glutamate addition and subsequent EC80 glutamate add
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[PMID: 30247901] |
Chemical Information
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CAS No. 1968546-34-0
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Masse moléculaire 400.41
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Formule C18H14F2N6OS
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SMILES
O=C(NC1CC(F)(F)C1)C2=NSC3=CC(NC4=NNC5=C4N=CC=C5)=CC=C32
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU6001376 Related Classifications
HY-112814 Related Classifications
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