1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. CYP17-IN-1

CYP17-IN-1 

Cat. No.: HY-101516
Handling Instructions

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM.

For research use only. We do not sell to patients.

CYP17-IN-1 Chemical Structure

CYP17-IN-1 Chemical Structure

CAS No. : 2093317-51-0

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Description

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1].

IC50 & Target

IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]

In Vitro

CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4[1].

In Vivo

CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].

Molecular Weight

312.40

Formula

C₁₈H₁₇FN₂S

CAS No.

2093317-51-0

SMILES

CC1=CC=NC=C1CN(CC2)CC3=C2C4=CC(F)=CC=C4S3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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CYP17-IN-1
Cat. No.:
HY-101516
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