Art. -Nr.: HY-N0662

Amentoflavone

(Synonyms: Didemethyl-ginkgetin)

19 Cited Publications

Kundenbewertung

Based on 19 publication(s) in Google Scholar

Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase.

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Reinheit: 99.66%
CAS. Nr.: 1617-53-4
Formel: C₃₀H₁₈O₁₀
Molecular Weight:538.46

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Amentoflavone Chemical Structure

CAS. Nr.: 1617-53-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (19)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.6 μg/mL Compound: 1	Cytotoxicity against A549 cells Cytotoxicity against A549 cells	[PMID: 17027271]
A549	IC₅₀	8.36 μM Compound: 10	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29921475]
B16	IC₅₀	1.6 μg/mL Compound: 1	Cytotoxicity against B16 cells Cytotoxicity against B16 cells	[PMID: 17027271]
Bel-7402	IC₅₀	1.6 μg/mL Compound: 1	Cytotoxicity against BEL-7402 cells Cytotoxicity against BEL-7402 cells	[PMID: 17027271]
BGC-823	IC₅₀	1.6 μg/mL Compound: 1	Cytotoxicity against BGC823 cells Cytotoxicity against BGC823 cells	[PMID: 17027271]
Calu-1	IC₅₀	>100 μM Compound: 6	Cytotoxicity against human Calu1 cells after 3 days Cytotoxicity against human Calu1 cells after 3 days	[PMID: 10843573]
DU-145	IC₅₀	1.6 μg/mL Compound: 1	Cytotoxicity against DU145 cells Cytotoxicity against DU145 cells	[PMID: 17027271]
Fibroblast	IC₅₀	1.8 μM Compound: 4	Inhibition of UVB irradiation-induced MMP1 production in human dermal fibroblasts after 48 hrs Inhibition of UVB irradiation-induced MMP1 production in human dermal fibroblasts after 48 hrs	[PMID: 18029185]
HCT-15	IC₅₀	>50 μM Compound: 8	Cytotoxicity against human HCT15 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human HCT15 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 23206866]
HEK293	IC₅₀	23.8 μM Compound: Amentoflavone	Inhibition of sPLA2-2A in HEK293 cell Inhibition of sPLA2-2A in HEK293 cell	[PMID: 16504502]
HEK293	IC₅₀	>100 μM Compound: amentoflavone	Inhibition of human cloned cPLA2 expressed in HEK293 cells Inhibition of human cloned cPLA2 expressed in HEK293 cells	[PMID: 17826099]
HEK293	IC₅₀	>100 μM Compound: amentoflavone	Inhibition of human cloned sPLA2-10 expressed in HEK293 cells Inhibition of human cloned sPLA2-10 expressed in HEK293 cells	[PMID: 17826099]
HEK293	IC₅₀	>100 μM Compound: amentoflavone	Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells	[PMID: 17826099]
HEK293	IC₅₀	41.8 μM Compound: amentoflavone	Inhibition of human cloned sPLA2-5 expressed in HEK293 cells Inhibition of human cloned sPLA2-5 expressed in HEK293 cells	[PMID: 17826099]
HeLa	IC₅₀	>100 μM Compound: 6	Cytotoxicity against human HeLa cells after 3 days Cytotoxicity against human HeLa cells after 3 days	[PMID: 10843573]
HeLa	IC₅₀	46.4 μM Compound: amentoflavone	Cytotoxicity against human HeLa cells assessed as growth inhibition by sulforhodamine B assay Cytotoxicity against human HeLa cells assessed as growth inhibition by sulforhodamine B assay	[PMID: 26722868]
HeLa	IC₅₀	5.3 μM Compound: 7	Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay	[PMID: 29475587]
HeLa	IC₅₀	>10 μM Compound: 66	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability Antiproliferative activity against human HeLa cells assessed as reduction in cell viability	[PMID: 30830783]
HepG2	IC₅₀	>50 μM Compound: 8	Cytotoxicity against human HepG2 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 23206866]
HepG2	IC₅₀	9.13 μM Compound: 10	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29921475]
HL-60	IC₅₀	>50 μM Compound: 8	Cytotoxicity against human HL60 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 23206866]
HL-60	IC₅₀	51.2 μM Compound: 7	Antiproliferative activity against human HL60 cells after 48 hrs by CCK8 assay Antiproliferative activity against human HL60 cells after 48 hrs by CCK8 assay	[PMID: 29475587]
HT-29	IC₅₀	1.6 μg/mL Compound: 1	Cytotoxicity against HT29 cells Cytotoxicity against HT29 cells	[PMID: 17027271]
Huh-7	CC₅₀	>50 μM Compound: 12	Cytotoxicity against human Huh7.5.1 cells by MTT assay Cytotoxicity against human Huh7.5.1 cells by MTT assay	[PMID: 22445328]
Jurkat	IC₅₀	>50 μM Compound: 8	Cytotoxicity against human Jurkat cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human Jurkat cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 23206866]
K562	IC₅₀	>100 μM Compound: 6	Cytotoxicity against human K562 cells after 3 days Cytotoxicity against human K562 cells after 3 days	[PMID: 10843573]
MCF7	IC₅₀	1.6 μg/mL Compound: 1	Cytotoxicity against MCF7 cells Cytotoxicity against MCF7 cells	[PMID: 17027271]
MCF7	IC₅₀	75.4 μM Compound: 4	Cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay	[PMID: 34875389]
MDA-MB-231	IC₅₀	1.6 μg/mL Compound: 1	Cytotoxicity against MDA-MB-231 cells Cytotoxicity against MDA-MB-231 cells	[PMID: 17027271]
MGC-803	IC₅₀	9.86 μM Compound: 10	Cytotoxicity against human MGC803 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MGC803 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29921475]
Monocyte	IC₅₀	3 μM Compound: amentoflavone	Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs	[PMID: 8882428]
Monocyte	IC₅₀	3 x 10^-6 M Compound: amentoflavone	Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs	[PMID: 8882428]
Neutrophil	IC₅₀	0.75 μM Compound: 7	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate	[PMID: 29381070]
Neutrophil	IC₅₀	1.01 μM Compound: 7	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase	[PMID: 29381070]
NIH3T3	IC₅₀	9.2 μM Compound: Amentoflavone	Inhibition of PDGF-induced phosphotidyl inositol turnover in PLCgamma1 expressing mouse NIH3T3 cells Inhibition of PDGF-induced phosphotidyl inositol turnover in PLCgamma1 expressing mouse NIH3T3 cells	[PMID: 10869194]
Oocyte	EC₅₀	3.6 μM Compound: Amentoflavone	Effective concentration against human recombinant GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in Xenopus oocytes Effective concentration against human recombinant GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in Xenopus oocytes	[PMID: 12824018]
PBMC	IC₅₀	35 μM Compound: 1	Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method Cytotoxicity against uninfected PHA-stimulated human PBMC assessed as thymidine incorporation after 24 hrs by trypan blue exclusion method	[PMID: 9322359]
Raji	IC₅₀	>100 μM Compound: 6	Cytotoxicity against human Raji cells after 3 days Cytotoxicity against human Raji cells after 3 days	[PMID: 10843573]
SGC-7901	IC₅₀	1.6 μg/mL Compound: 1	Cytotoxicity against SGC7901 cells Cytotoxicity against SGC7901 cells	[PMID: 17027271]
SW480	IC₅₀	111 μM Compound: 9	Cytotoxicity against human SW480 cells after 72 hrs by MTT assay Cytotoxicity against human SW480 cells after 72 hrs by MTT assay	[PMID: 15787435]
T-24	IC₅₀	10.67 μM Compound: 10	Cytotoxicity against human T24 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human T24 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29921475]
THP-1	IC₅₀	>50 μM Compound: 8	Cytotoxicity against human THP1 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human THP1 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 23206866]
U-937	IC₅₀	>50 μM Compound: 8	Cytotoxicity against human U937 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human U937 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 23206866]
Vero	IC₅₀	>100 μM Compound: 6	Cytotoxicity against african green monkey Vero cells after 3 days Cytotoxicity against african green monkey Vero cells after 3 days	[PMID: 10843573]
WISH	IC₅₀	>100 μM Compound: 6	Cytotoxicity against human Wish cells after 3 days Cytotoxicity against human Wish cells after 3 days	[PMID: 10843573]

In Vitro

Amentoflavone (1-60 μM) inhibits the production of nitric oxide in a concentration-dependent manner in RAW 264.7 cells^[2].
Amentoflavone (50-200 μM) inhibits the viability of U-87 MG cells with IC₅₀ value of 100 μM at 48 h^[3].
Amentoflavone (0, 50, 100 μM; 48 h) induces apoptosis and cell cycle arrest at sub-G1 phase^[3].
Amentoflavone (0, 50, 100 μM; 48 h) inhibits NF- B activation and decreases the expression of MCL1 and C-FLIP protein in U-87 MG cells^[3].
Amentoflavone (0-32 μg/ml) shows antibacterial activity with MICs of 8, 4, 32, 8, 16, 8 μg/ml for E. faecium ATCC 19434, S. aureus ATCC 25923, S. mutans ATCC 3065, E. coli O-157 ATCC 25922, E. coli ATCC 43895, P. aeruginosa ATCC 27853, respectively^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

U-87 MG cells
Concentration:

0, 50, 75, 100, 200 µM
Incubation Time:

48 h
Result:

Significantly inhibited the viability of U-87 MG cells by 23-71% with an IC₅₀ value of 100 µM at 48 h.

Apoptosis Analysis^[3]

Cell Line:

U-87 MG cells
Concentration:

0, 50, 100 µM
Incubation Time:

48 h
Result:

Significantly induced the accumulation of cells in the sub-G1 population and increased the level of active caspase-3 by 14-52% and 24-42%, respectively, and significantly triggered the loss of Ψm and the expression of active caspase-8 by 23-53% and 25-50%, respectively.

Western Blot Analysis^[3]

Cell Line:

U-87 MG cells
Concentration:

0, 50, 100 µM
Incubation Time:

48 h
Result:

Significantly reduced NF-ĸB activation in a dose-dependent manner by 25-87% and reduced protein expression of MCL1 and C-FLIP by 50-80% and 38-57%, respectively.

In Vivo

Amentoflavone (25 mg/kg; p.o.; once a day for 3 consecutive days) shows neuroprotective role in epilepsy via anti-inflammatory effects in mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

5-6 weeks, 28-32 g, kunming mice^[1]
Dosage:

25 mg/kg
Administration:

P.o.; once a day for 3 consecutive days
Result:

Inhibited activation and nuclear translocation of NF-κB subunits p65, decreased IL-6 and IL-1β production and significantly decreased NO and prostaglandin E2 production.

Chemical Information

CAS. Nr. 1617-53-4
Appearance Solid
Molecular Weight 538.46
Formel C₃₀H₁₈O₁₀
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13
Synonyms

Didemethyl-ginkgetin
Structure Classification
- Flavonoids
- Biflavones
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (19)

All WBCell Imaging/StainingHistological Imaging/StainingCell Proliferation/Viability AssayIF

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Journal Impact Factor

Acta Pharm Sin B

Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]

2021 Jan;11(1):143-155. PMID: 33532186
Pharmacol Res

Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis. [Abstract]

2020 May;155:104751. PMID: 32151678
Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Phytomedicine

Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING/NLRP3 signalling pathway. [Abstract]

2023 Aug:117:154922. PMID: 37321078

Amentoflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Aug:117:154922. [Abstract]

Mice were subjected to a 2-week intraperitoneal injection of saline (vehicle) or DOX with or without the combined administration of Amentoflavone (AMF) (20 mg/kg) and/or nigericin, Representative western blot.

Amentoflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Aug:117:154922. [Abstract]

Mice were subjected to a 2-week intraperitoneal injection of saline (vehicle) or DOX with or without the combined administration of Amentoflavone (AMF) (20 mg/kg) and/or nigericin, Representative images of TUNEL staining.

Amentoflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Aug:117:154922. [Abstract]

Mice were subjected to a 2-week intraperitoneal injection of saline (vehicle) or DOX with/without combined administration of Amentoflavone (AMF) (20 mg/kg), Representative images of the hematoxylineosin (HE) staining .

Amentoflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Aug:117:154922. [Abstract]

Primary cardiomyocytes were subjected to saline (vehicle) or DOX (1 µM, 24 h) with/without combined incubation of Amentoflavone (AMF, 20 µM,24 h) and/or ABZI (1 µM, 3 h). Viability of cardiomyocytes was measured using the CCK-8 assay.

Amentoflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Aug:117:154922. [Abstract]

Primary cardiomyocytes were subjected to saline (vehicle) or DOX (1 µM, 24 h) with/without combined incubation of Amentoflavone (AMF, 20 µM,24 h) and/or ABZI (1 µM, 3 h). Representative immunofluorescence staining of GSDMD-N.
J Med Chem

Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. [Abstract]

2021 Aug 26;64(16):12089-12108. PMID: 34404206
Phytother Res

Amentoflavone, a Preferentially TGF-β Receptor 1 Inhibitor, Alleviates Cardiac Remodeling and Dysfunction Through Modulating the TGF-β/Smad and MAPK Signaling Pathways. [Abstract]

2026 May;40(5):2380-2396. PMID: 41684292
J Agric Food Res

2026 Jan 16;26:102684.
J Ethnopharmacol

Amentoflavone from Ginkgo biloba inhibits EMT-driven lung cancer metastasis by targeting TGFBR2: Integrative network pharmacology, machine learning, and experimental validation. [Abstract]

2025 Dec 16:359:121061. PMID: 41412234
Life Sci

Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma. [Abstract]

2020 Apr 15;247:117425. PMID: 32057904
J Photochem Photobiol B

Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation. [Abstract]

2025 Dec 16:274:113343. PMID: 41421059
Naunyn Schmiedebergs Arch Pharmacol

Amentoflavone alleviated cartilage injury and inflammatory response of knee osteoarthritis through PTGS2. [Abstract]

2024 Nov;397(11):8903-8916. PMID: 38856914
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
S Afr J Bot

2025 Sep.
Cell Biochem Biophys

Amentoflavone Induces Ferroptosis to Alleviate Proliferation, Migration, Invasion and Inflammation in Rheumatoid Arthritis Fibroblast-like Synoviocytes by Inhibiting PIN1. [Abstract]

2025 Mar;83(1):1299-1312. PMID: 39354278
Sex Med

Hinokiflavone alleviates high-fat diet-induced erectile dysfunction via the EGFR/PI3K/Akt/eNOS signaling pathway. [Abstract]

2025 Aug 6;13(4):qfaf059. PMID: 40808867
Anticancer Res

Amentoflavone Induces Cell-cycle Arrest, Apoptosis, and Invasion Inhibition in Non-small Cell Lung Cancer Cells. [Abstract]

2021 Mar;41(3):1357-1364. PMID: 33788727
SSRN

2026 Jun 9.
Research Square Preprint

2024 Mar 15.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (185.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8571 mL

9.2857 mL

18.5715 mL

5 mM

0.3714 mL

1.8571 mL

3.7143 mL

10 mM

0.1857 mL

0.9286 mL

1.8571 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.5 mg/mL (4.64 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
SDS (393 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang Z, et al. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects. Neural Regen Res. 2015 Jul;10(7):1125-33. [Content Brief]

[2]. Woo ER, et al. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Pharmacol Res. 2005 Jun;51(6):539-46. [Content Brief]

[3]. Yen TH, et al. Amentoflavone Induces Apoptosis and Inhibits NF-ĸB-modulated Anti-apoptotic Signaling in Glioblastoma Cells. In Vivo. 2018 Mar-Apr;32(2):279-285. [Content Brief]

[4]. Hwang JH, et al. Antibacterial effect of amentoflavone and its synergistic effect with antibiotics. J Microbiol Biotechnol. 2013;23(7):953-8. [Content Brief]

[5]. Hanrahan JR, et al. Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8571 mL	9.2857 mL	18.5715 mL	46.4287 mL
	5 mM	0.3714 mL	1.8571 mL	3.7143 mL	9.2857 mL
	10 mM	0.1857 mL	0.9286 mL	1.8571 mL	4.6429 mL
	15 mM	0.1238 mL	0.6190 mL	1.2381 mL	3.0952 mL
	20 mM	0.0929 mL	0.4643 mL	0.9286 mL	2.3214 mL
	25 mM	0.0743 mL	0.3714 mL	0.7429 mL	1.8571 mL
	30 mM	0.0619 mL	0.3095 mL	0.6190 mL	1.5476 mL
	40 mM	0.0464 mL	0.2321 mL	0.4643 mL	1.1607 mL
	50 mM	0.0371 mL	0.1857 mL	0.3714 mL	0.9286 mL
	60 mM	0.0310 mL	0.1548 mL	0.3095 mL	0.7738 mL
	80 mM	0.0232 mL	0.1161 mL	0.2321 mL	0.5804 mL
	100 mM	0.0186 mL	0.0929 mL	0.1857 mL	0.4643 mL

Amentoflavone

19 Cited Publications

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Amentoflavone

Anti-Infection Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Membrane Transporter/Ion Channel Compound Library

Metabolism/Protease Compound Library

Neuronal Signaling Compound Library

NF-κB Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Antiviral Compound Library

Anti-Aging Compound Library

Anti-diabetic Compound Library

Antifungal Compound Library

Antibacterial Compound Library

Medicine Food Homology Compound Library

Phenols Library

Orally Active Compound Library

Neurotransmitter Receptor Compound Library

Traditional Chinese Medicine Active Compound Library

Flavonoids Library

Anti-Alzheimer's Disease Compound Library

Neuroprotective Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Cancer Natural Product Library

Antiviral Traditional Chinese Medicine Active Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

GABA Receptor Compound Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cell Death Library

Ion Channel Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

RNA Binding Bioactive Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Amentoflavone

Biologische Aktivität

Chemical Information

Publications (19)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Amentoflavone Related Classifications

HY-N0662 Related Classifications