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Art. -Nr.: HY-101632

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Irindalone

Name: Irindalone
Brand: MedChemExpress
SKU: HY-101632
Availability: PreOrder

(Synonyms: Lu 21-098)

Irindalone is a novel serotonin 5-HT₂ antagonist.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 96478-43-2
Formel: C₂₄H₂₉FN₄O
Molecular Weight:408.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Irindalone Chemical Structure

CAS. Nr.: 96478-43-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Irindalone is a novel serotonin 5-HT₂ antagonist.

IC₅₀ & Target

5-HT₂ Receptor

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Irindalone causes a concentration-related inhibition of serotonin-induced contractions and shifts the serotonin curve to the right. Irindalone is more potent in inhibiting the serotonin-induced contractions. Irindalone has a similar profile in vitro, with a high affinity for serotonin 5-HT₂ receptors and about a 10 times lower affinity for α₁-adrenoceptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Irindalone dose dependently lowers the blood pressure in spontaneously hypertensive rats (SHR) and renal hypertensive dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 96478-43-2
Molecular Weight 408.51
Formel C₂₄H₂₉FN₄O
SMILES

O=C1NCCN1CCN2CCN([C@@H]3C[C@@H](C4=CC=C(F)C=C4)C5=C3C=CC=C5)CC2
Synonyms

Lu 21-098
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mikkelsen EO, et al. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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