Kaolin
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Kaolin is a family of kaolinitic clays, which is found in the earth's crust. Kaolin alleviates the toxicity of graphene oxide for mammalian cells. Kaolin can be utilized in industrial, cosmetic and medical fields, excipient.
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- CAS. Nr.: 1332-58-7
- Formel: Al2Si2O5(OH)4·2H2O
- Molecular Weight:258.16
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Speicherung:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Kaolin (50, 100 μg/mL, 72 h) combined with graphene oxide (50, 100 μg/mL, 72 h) reduces the toxicity of graphene and decreases the percentage of cells in HCT-116 cells[3].
Kaolin (100 μg/mL, 30-180 min) induces intercellular ROS generation in RAW264 cells[4].
Kaolin (100 μg/mL, 24 h) increases the concentrations of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in RAW264 cells[4].
Kaolin (100 μg/mL, 60 min) increases DNA damage in the A549 cells co-cultured with RAW264 cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Kaolin (5.0/0.1 mg/mL in 0.15 M NaCl, intratracheal inoculation, lasting for 24 h-210 days) incites acute inflammatory reaction at early periods and increases in the fibroblastic activity in the focal areas in mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice[4]
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Dosage:0.05 and 0.2 mg
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Administration:intratracheal instillation, lasting for 3 h
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Result:Significantly induced DNA damage in the lungs of the mice.
Chemical Information
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CAS. Nr. 1332-58-7
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Appearance Solid
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Molecular Weight 258.16
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Formel Al2Si2O5(OH)4·2H2O
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Color White to off-white
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SMILES
[Kaolin]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (421 KB)
- English - EN (421 KB)
- Français - FR (421 KB)
- Deutsch - DE (421 KB)
- Norwegian - NO (421 KB)
- Español - ES (421 KB)
- Swedish - SV (421 KB)
- Italian - IT (421 KB)
- Korean - KR (421 KB)
- Portuguese - PT (421 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. [Content Brief]
[3]. Rozhina E, et al. Kaolin alleviates the toxicity of graphene oxide for mammalian cells. Medchemcomm. 2019 Jun 10;10(8):1457-1464. [Content Brief]
[4]. Kato T, et al. Effect of physicochemical character differences on the genotoxic potency of kaolin. Genes Environ. 2017 May 1;39:12. [Content Brief]
[5]. Sahu AP, Shanker R, Zaidi SH. Pulmonary response to kaolin, mica and talc in mice. Exp Pathol (Jena). 1978;16(1-6):276-82. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Kaolin Related Classifications
HY-W115786 Related Classifications
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- Kaolin
- 1332-58-7
- Environmental Pollutants
- TNF Receptor
- Reactive Oxygen Species (ROS)
- Biochemical Assay Reagents
- Interleukin Related
- pharmaceutical excipient
- pharmaceutical auxiliarie
- pharmaceutical ingredients
- inactive ingredients
- stability
- solubility
- processability
- absorption
- distribution
- metabolism
- and elimination (ADME)
- Inhibitor
- inhibitor
- inhibit