Phe-PEG1-Dasa
Phe-PEG1-Dasa is a BCR-ABL PROTAC degrader, with its DC50 being 1.56 nM. Phe-PEG1-Dasa uses a single amino acid (Phe) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, thus being called a mini-PROTAC. Phe-PEG1-Dasa significantly inhibits the proliferation of K562 cells. Phe-PEG1-Dasa can be used for the study of leukemia.
(Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0215); Black: linker).
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- CAS. Nr.: 3037776-73-8
- Formel: C36H44ClN9O5S
- Molecular Weight:750.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Bcr-Abl 1.56 nM (DC50) |
Chemical Information
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CAS. Nr. 3037776-73-8
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Molecular Weight 750.31
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Formel C36H44ClN9O5S
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SMILES
N[C@@H](CC1=CC=CC=C1)C(NCCOCCC(OCCN(CC2)CCN2C3=NC(C)=NC(NC4=NC=C(C(NC5=C(C=CC=C5Cl)C)=O)S4)=C3)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Phe-PEG1-Dasa Related Classifications
HY-180962 Related Classifications
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