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Cat. No.: HY-N19700

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Calphostin D

Calphostin D is a protein kinase C (Protein Kinase, PKC) inhibitor with an IC₅₀ of 6.4 μM. Calphostin D achieves selective inhibition by interacting with the unique C1 regulatory domain of PKC. As a photosensitizer, Calphostin D generates reactive oxygen species upon exposure to light. Calphostin D can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 124986-26-1
Formula: C₃₀H₃₀O₁₀
Molecular Weight:550.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Calphostin D Chemical Structure

CAS No.: 124986-26-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PKC

6.4 μM (IC₅₀)

All PKC Isoforms :

In Vitro

Calphostin D inhibits full-length PKC with an IC₅₀ of 6.4 μM, acting via the enzyme's regulatory domain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 124986-26-1
Molecular Weight 550.55
Formula C₃₀H₃₀O₁₀
SMILES

O=C(C1=C2C(C3=C(OC)C=C(O)C4=C53)=C(OC)C=C1O)C(OC)=C(C[C@H](O)C)C2=C5C(C[C@H](O)C)=C(OC)C4=O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. Journal of the American Chemical Society. 2009 Jul 08;131(26):9413-25. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Calphostin D

All PKC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Calphostin D Related Classifications

HY-N19700 Related Classifications