DC-U4106
Based on 1 publication(s) in Google Scholar
DC-U4106 is a USP8 targeting inhibitor with the Kdvalue of 4.7 μM and the IC50 value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer.
For research use only. We do not sell to patients.
- Purity: 98.09%
- CAS No.: 2410534-62-0
- Formula: C29H27N5O5
- Molecular Weight:525.56
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DC-U4106
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Biological Activity
Kd: 4.7 μM (USP8), IC50: 1.2 μM (USP8)[1].
DC-U4106 (1.2-45.2 μM) inhibits USP8 and USP2 with the IC50 values of 1.2 μM and 58.4 μM, respectively, and no activity in USP7[1]. DC-U4106 (0-7 μM, 24 hours) reduces mRNA levels of ERα and PR[1]. DC-U4106 (0-5 μM, 24 hours) can regulate the RTK pathway related proteins and the expression of ERα and PR proteins[1]. DC-U4106 (0-5 μM, 12 hours) can induce apoptosis and inhibit cell proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:USP8-positive cell line MCF-7
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Concentration:0-5 μM
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Incubation Time:24 hours
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Result:Reduced the expression of EGFR, ErbB2, and ErbB3 proteins with increasing concentrations and caused degradation of ERα and PR proteins.
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Cell Line:USP8-positive cell line MCF-7
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Concentration:0-7 μM
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Incubation Time:24 hours
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Result:Reduced mRNA levels of ERα and PR.
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Cell Line:USP8-positive cell line MCF-7
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Concentration:0-5 μM
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Incubation Time:
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Result:Inhibited cell growth in a dose-dependent manner.
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Cell Line:USP8-positive cell line MCF-7
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Concentration:0-5 μM
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Incubation Time:12 hours
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Result:Resulted in increasing in the proportion of apoptotic cells with increasing concentrations.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice[1]
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Dosage:5 mg/kg , 20 mg/kg
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Administration:Intraperitoneal injection, Every 2 days, 14 days
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Result:Inhibited tumor growth significantly at a concentration of 20 mg/kg.
Chemical Information
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CAS No. 2410534-62-0
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Appearance Solid
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Molecular Weight 525.56
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Formula C29H27N5O5
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Color Yellow to brown
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SMILES
O=C1C=C(C2=CC=C(N3CCN(C4=NC=CC=C4)CC3)C=C2)OC5=C1C(O)=CC(O)=C5OC6=C(C)NN=C6C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 25 mg/mL (47.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
THF : 10 mg/mL (19.03 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| THF / DMSO | 1 mM | 1.9027 mL | 9.5137 mL | 19.0273 mL | 47.5683 mL |
| 5 mM | 0.3805 mL | 1.9027 mL | 3.8055 mL | 9.5137 mL | |
| 10 mM | 0.1903 mL | 0.9514 mL | 1.9027 mL | 4.7568 mL | |
| 15 mM | 0.1268 mL | 0.6342 mL | 1.2685 mL | 3.1712 mL | |
| DMSO | 20 mM | 0.0951 mL | 0.4757 mL | 0.9514 mL | 2.3784 mL |
| 25 mM | 0.0761 mL | 0.3805 mL | 0.7611 mL | 1.9027 mL | |
| 30 mM | 0.0634 mL | 0.3171 mL | 0.6342 mL | 1.5856 mL | |
| 40 mM | 0.0476 mL | 0.2378 mL | 0.4757 mL | 1.1892 mL |
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