trans-Coniferyl aldehyde
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID50 value of 0.76 μM,and has the antimutagenic activities against furylfuramide, Trp-P-1, and activated Trp-P-1.
For research use only. We do not sell to patients.
- CAS No.: 20649-42-7
- Formula: C10H10O3
- Molecular Weight:178.18
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Size
Price
Stock
Quantity
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
trans-Coniferyl aldehyde (compound 2) is a natural compound isolated from the buds of clove (Syzygium aromaticum).trans-Coniferyl aldehyde suppresses 63% of the UV mutable gene expression at 1.20 μM, and with an ID50 value of 0.76 μM,and has the antimutagenic
activities against furylfuramide, Trp-P-1, and activated Trp-P-1[1].
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
1.7 μM
Compound: 10
|
Growth inhibition of human A549 cells by Sulforhodamine B assay
Growth inhibition of human A549 cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| A549 | IC50 |
21.18 μM
Compound: 19
|
Anticancer activity against human A549 cells by SRB assay
Anticancer activity against human A549 cells by SRB assay
|
[PMID: 21420296] |
| A549 | IC50 |
59 μM
Compound: 30
|
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| B16-4A5 | IC50 |
15.3 μM
Compound: 15
|
Antimelanogenic activity in theophylline-stimulated mouse B16-4A5 cells assessed as inhibition of melanogenesis after 72 hrs relative to control
Antimelanogenic activity in theophylline-stimulated mouse B16-4A5 cells assessed as inhibition of melanogenesis after 72 hrs relative to control
|
[PMID: 27756508] |
| HeLa | GI50 |
61.8 μM
Compound: 10
|
Growth inhibition of human HeLa cells by Sulforhodamine B assay
Growth inhibition of human HeLa cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| HeLa | EC50 |
9.03 μM
Compound: 5
|
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
Induction of cell surface translocation of MR1 in human HeLa overexpressing MR1 assessed as increase in MR1 cell surface levels incubated for 8 hrs followed by labeling with PE-conjugated anti-hMR1 antibody by flow cytometry analysis
|
[PMID: 37638616] |
| HT-1080 | ED50 |
4.05 μg/mL
Compound: 9
|
Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 24 hrs by MTT assay
|
[PMID: 9677271] |
| LoVo | IC50 |
23 μM
Compound: 30
|
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| MCF7 | GI50 |
39.5 μM
Compound: 10
|
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| PC-3 | IC50 |
35 μM
Compound: 30
|
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| RAW264.7 | IC50 |
>0.3 mM
Compound: 30
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
|
[PMID: 18986199] |
| RAW264.7 | IC50 |
>0.3 μM/mL
Compound: 30
|
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
|
[PMID: 18986199] |
| SK-MEL-2 | IC50 |
>30 μM
Compound: 19
|
Anticancer activity against human SK-MEL-2 cells by SRB assay
Anticancer activity against human SK-MEL-2 cells by SRB assay
|
[PMID: 21420296] |
| SK-MEL-28 | IC50 |
33 μM
Compound: 30
|
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| SK-N-SH | GI50 |
10.6 μM
Compound: 10
|
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| SK-OV-3 | IC50 |
>30 μM
Compound: 19
|
Anticancer activity against human SKOV3 cells by SRB assay
Anticancer activity against human SKOV3 cells by SRB assay
|
[PMID: 21420296] |
| U-373MG ATCC | IC50 |
28 μM
Compound: 30
|
Cytotoxicity against human U373 cells after 72 hrs by MTT assay
Cytotoxicity against human U373 cells after 72 hrs by MTT assay
|
[PMID: 21696954] |
| XF498 | IC50 |
>30 μM
Compound: 19
|
Anticancer activity against human XF498 cells by SRB assay
Anticancer activity against human XF498 cells by SRB assay
|
[PMID: 21420296] |
Chemical Information
-
CAS No. 20649-42-7
-
Molecular Weight 178.18
-
Formula C10H10O3
-
SMILES
O=C/C=C/C1=CC(OC)=C(C=C1)O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
References
Calculators
Molarity Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
=
×
×
Dilution Calculator
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz