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Cat. No.: HY-148231

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Dideoxy-amanitin

Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC₅₀ value of 74.2 nM.

For research use only. We do not sell to patients.

CAS No.: 58255-46-2
Formula: C₃₉H₅₄N₁₀O₁₂S
Molecular Weight:886.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Dideoxy-amanitin Chemical Structure

CAS No.: 58255-46-2

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC₅₀ value of 74.2 nM^[1].

IC₅₀ & Target

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

All ADC Payloads Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	1.3 μM Compound: Dideoxy amanitin	Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 35696491]

In Vitro

Dideoxy-amanitin (compound 2; 0.078-20 μM; 24 h) has cell cytotoxicity in CHO (Chinese hamster ovary) cells with an IC₅₀ value of 0.3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

CHO (Chinese hamster ovary) cells
Concentration:

0.078-20 μM
Incubation Time:

24 hours
Result:

Decreased cell proliferation in a dose-depengdent manner.

Chemical Information

CAS No. 58255-46-2
Molecular Weight 886.97
Formula C₃₉H₅₄N₁₀O₁₂S
SMILES

C[C@H]([C@H](NC([C@@H]1C[C@@H](O)CN1C([C@@H]2CC(N)=O)=O)=O)C(N[C@@H](CC3=C(SC[C@H](N4)C(N2)=O)NC5=C3C=CC=C5)C(NCC(N[C@H](C(NCC4=O)=O)[C@@H](C)CC)=O)=O)=O)[C@@H](O)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Matinkhoo K, et, al. Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates. Chemistry. 2021 Jul 16;27(40):10282-10292. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Dideoxy-amanitin

All DNA/RNA Synthesis Isoforms

All ADC Payloads Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Dideoxy-amanitin Related Classifications

HY-148231 Related Classifications