LC-2 epimer
LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849.
(Pink: KRas G12C ligand (HY-130149); Blue: VHL ligand (HY-125845B); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2502156-12-7
- Formula: C59H71ClFN11O7S
- Molecular Weight:1132.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- Purity & Documentation
- References
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Biological Activity
Description
Chemical Information
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CAS No. 2502156-12-7
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Molecular Weight 1132.78
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Formula C59H71ClFN11O7S
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SMILES
O=C(N1[C@@H](C[C@@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCCN(CCC4)[C@@H]4COC5=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C7C(CN(C8=CC=CC9=C8C(Cl)=CC=C9)CC7)=N5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LC-2 epimer Related Classifications
HY-137516A Related Classifications
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