Litoxetine
Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT3 receptor antagonist with a Ki of 85 nM for cerebral 5-HT3 receptors. Litoxetine is an antidepressant and has antiemetic properties.
For research use only. We do not sell to patients.
- CAS No.: 86811-09-8
- Formula: C16H19NO
- Molecular Weight:241.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.3 μM
Compound: Litoxetine
|
Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells
Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cells
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[PMID: 19282174] |
| HEK293 | IC50 |
1.4 μM
Compound: 4
|
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting
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[PMID: 19740658] |
| HEK293 | IC50 |
5.9 nM
Compound: 4
|
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting
|
[PMID: 19740658] |
| HEK293 | IC50 |
6 nM
Compound: Litoxetine
|
Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells
Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cells
|
[PMID: 19282174] |
| HEK293 | IC50 |
6.5 μM
Compound: Litoxetine
|
Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells
Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cells
|
[PMID: 19282174] |
| HEK293 | IC50 |
6.7 μM
Compound: 4
|
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting
|
[PMID: 19740658] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 86811-09-8
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Molecular Weight 241.33
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Formula C16H19NO
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SMILES
C1(COC2CCNCC2)=CC3=C(C=CC=C3)C=C1
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Synonyms
SL 81.0385
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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