NLX-266
NLX-266 is an orally active ERK1/2-biased 5-HT1A receptor agonist. NLX-266 can be used in the study of Parkinson's disease.
For research use only. We do not sell to patients.
- CAS No.: 2170564-20-0
- Formula: C20H21ClF3N3O2
- Molecular Weight:427.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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All 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
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5-HT1A Receptor |
Chemical Information
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CAS No. 2170564-20-0
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Molecular Weight 427.85
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Formula C20H21ClF3N3O2
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SMILES
O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCCOC3=NC=CC(F)=C3)(F)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLX-266 Related Classifications
HY-172924 Related Classifications
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