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Cat. No.: HY-103126

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DR4485 hydrochloride

DR4485 (hydrochloride) is an orally active and selective 5-HT₇ antagonist (pK_i=8.14).

For research use only. We do not sell to patients.

CAS No.: 402942-53-4
Formula: C₂₆H₂₉Cl₃N₂O
Molecular Weight:491.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DR4485 hydrochloride Chemical Structure

CAS No.: 402942-53-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DR4485 (hydrochloride) is an orally active and selective 5-HT₇ antagonist (pK_i=8.14)^[1].

IC₅₀ & Target^[1]

5-HT₇ Receptor

8.14 (pKi)

All 5-HT Receptor Isoforms :

In Vitro

DR4485 (MZ54 WT cells; 6 μM or 8 μM) hydrochloride induces autophagy as well as cell death that is diminished by KO of ATG5 and ATG7^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 402942-53-4
Molecular Weight 491.88
Formula C₂₆H₂₉Cl₃N₂O
SMILES

O=C1NC2=C3C1(CCCCN4CC=C(C5=CC=C(Cl)C=C5)CC4)CCCC3=C(Cl)C=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kikuchi C, et al. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorg Med Chem Lett. 2003;13(1):61-64. [Content Brief]

[2]. Meyer N, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death [published online ahead of print, 2021 Jan 19]. Autophagy. 2021;1-20. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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DR4485 hydrochloride

High-Throughput Bioactive Compound Library

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DR4485 hydrochloride Related Classifications

HY-103126 Related Classifications