Eptapirone fumarate
Eptapirone fumarate (F11440 fumarate) is a potent, selective and orally active 5-HT1A receptor agonist (pKi = 8.33). Eptapirone fumarate can inhibit cAMP production. Eptapirone fumarate can reduce 5-HT levels and increase corticosterone levels. Eptapirone fumarate shows potent anxiolytic and antidepressant potential. Eptapirone fumarate can be used for the research of neurological disease, such as anxiety and depression.
For research use only. We do not sell to patients.
- CAS No.: 179756-85-5
- Formula: C20H27N7O6
- Molecular Weight:461.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT1A Receptor |
Eptapirone fumarate (0.01-0.63 mg/kg, i.p.) reduces 5-HT levels in microdialysates from the ventral hippocampus of rats[1].
Eptapirone fumarate (0.0063-160 mg/kg, p.o.) increases plasma corticosterone levels in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Anxiety and depression rats models[1]
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Dosage:0.16, 0.63, 2.5, 10, 40, 160 and 640 mg/kg
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Administration:Orally administration
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Result:Increased punished responding in a pigeon conflict procedure.
Decreased immobility in a rat forced swimming test.
Chemical Information
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CAS No. 179756-85-5
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Molecular Weight 461.47
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Formula C20H27N7O6
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SMILES
O=C(O)/C=C/C(O)=O.O=C(N1C)N(CCCCN2CCN(C3=NC=CC=N3)CC2)N=CC1=O
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Synonyms
F 11440 fumarate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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