Glenthmycin L
Glenthmycin L is a potent antibiotic that can be found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin L exhibits antibacterial activity against Gram-positive bacterial pathogens including Staphylococcus aureus, Enterococcus faecalis, Methicillin (HY-B0974)-resistant Staphylococcus aureus, and Vancomycin (HY-B0671)-resistant Enterococci. Glenthmycin L can be used for the research of bacterial infections caused by Gram-positive pathogens.
For research use only. We do not sell to patients.
- CAS No.: 3040055-91-9
- Formula: C35H46O6
- Molecular Weight:562.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Glenthmycin L (0.01-30 μM; 16-24 h) potently inhibits growth of Staphylococcus aureus (ATCC 25923) with an IC50 of 0.8 μM, methicillin-resistant S. aureus (ATCC 43300) with an IC50 of 0.3 μM, Enterococcus faecalis with an IC50 of 3.0 μM, methicillin-resistant S. aureus (ATCC 33591) with an IC50 of 6.8 μM, and vancomycin-resistant Enterococci with an IC50 of 6.7 μM[1].
Glenthmycin L (30 μM; 48 h) shows no significant cytotoxicity against SW620 human colorectal carcinoma cells or NCI-H460 human lung carcinoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW620 human colorectal carcinoma cells, NCI-H460 human lung carcinoma cells
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Concentration:30 μM
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Incubation Time:48 h
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Result:Did not exhibit significant cytotoxicity against SW620 or NCI-H460 cells.
Showed no indication of reduced cell viability relative to the negative control.
Chemical Information
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CAS No. 3040055-91-9
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Molecular Weight 562.75
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Formula C35H46O6
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SMILES
OC=1[C@@]23[C@@](C=C(C)[C@H](C)C2)(/C=C(\C)/CC/C=C(\C)/[C@]4([C@@](C)(C(=O)C1C(=O)O3)[C@]5([C@@]([C@@H](OC(C)=O)CC[C@@H]5C)(C=C4C)[H])[H])[H])[H]
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Structure Classification
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Initial Source
Streptomyces sp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glenthmycin L Related Classifications
HY-N19214 Related Classifications
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- Glenthmycin L
- 3040055-91-9
- Antibiotic
- Bacterial
- human carcinoma cells
- methicillin-resistant Staphylococcus aureus
- SW620 human colorectal carcinoma cells
- Mycobacterium species
- vancomycin-resistant Enterococci
- Enterococcus faecalis
- Gram-positive bacterial pathogens
- Streptomyces sp. CMB-PB041
- Staphylococcus aureus
- NCI-H460 human lung carcinoma cells
- Inhibitor
- inhibitor
- inhibit