Ferrocin A
Ferrocin A is a lipopeptide compound that targets the SARS-CoV-2 RNA-dependent RNA polymerase (nsp12). Ferrocin A can stably bind to nsp12, and as an iron-chelating peptide, it reduces the concentration of free iron in the environment via complexation, thereby inhibiting bacterial growth by repressing the acquisition of essential metal cations. As an iron-chelating antiviral molecule, Ferrocin A may be used in studies related to COVID-19 and bacterial infections.
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- CAS No.: 114550-08-2
- 화학식: C51H82FeN13O19
- 분자량:1237.12
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
All Antibiotic Isoforms
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Biological Activity
제품 설명
Chemical Information
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CAS No. 114550-08-2
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분자량 1237.12
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화학식 C51H82FeN13O19
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SMILES
O=C1OCC(C(NC2C(NCC(NC(C(C)C)C(NC(CO)C(NC3C(NC(C)C(NCC(NC(CCCN4[O-][Fe+3]56(O=C(C)N(CCC2)[O-]5)(O=C(C)N(CCC3)[O-]6)O=C4C)C(NC1)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(C/C=C/CCCCCC)=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Aerobic Bacterial Batch Culture on Broth/Agar
Aerobic bacterial batch culture grows a closed inoculated population in broth or on agar without continuous medium replacement; growth readouts include turbidity/OD for total suspended biomass and colony-forming units for viable cells able to form colonies on agar. OD-based growth curves reflect light scattering by cells, but OD is instrument-, pathlength-, species-, cell-size-, and density-dependent, so OD should be calibrated or interpreted alongside viable counts when quantitative cell density is required.
순도&문서
References
[1]. Xia B, et al. Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking. Biomed J. 2021 Dec;44(6 Suppl 1):S15-S24. [Content Brief]
[2]. Katayama N, et al. Ferrocins, new iron-containing peptide antibiotics produced by bacteria. Taxonomy, fermentation and biological activity. J Antibiot (Tokyo). 1993 Jan;46(1):65-70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ferrocin A Related Classifications
HY-N14351 Related Classifications
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