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Fimepinostat mesylate

(Synonyms: CUDC-907 mesylate)
15 Cited Publications
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Based on 15 publication(s) in Google Scholar

Fimepinostat mesylate potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

For research use only. We do not sell to patients.

  • CAS No.: 1401998-36-4
  • Formula: C24H28N8O7S2
  • Molecular Weight:604.66
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Fimepinostat mesylate Chemical Structure
    Fimepinostat mesylate Chemical Structure
  • Experimental Validation Results for Fimepinostat mesylate
  • Experimental Validation Results for Fimepinostat mesylate
  • Experimental Validation Results for Fimepinostat mesylate
  • Experimental Validation Results for Fimepinostat mesylate
  • Experimental Validation Results for Fimepinostat mesylate
  • Experimental Validation Results for Fimepinostat mesylate
CAS No.: 1401998-36-4
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Cell Proliferation/Viability AssayIFWBIHCIn Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • WB
  • In Vivo Efficacy Study
  • IF
  • IHC
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All PI3K Isoforms

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All HDAC Isoforms

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  • Fimepinostat mesylate Chemical Structure
    Fimepinostat mesylate Chemical Structure
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    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2025 Jun 2;135(11):e187490. [Abstract]

    Customer Validation
     The indicated cell lines were treated with Fimepinostat , and cell viability was measured by CellTiter-Glo assays. IC50 values are shown.

  • 1/16

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2025 Jun 2;135(11):e187490. [Abstract]

    Customer Validation
     The indicated cell lines were treated with 5 nM Fimepinostat, 2 nM Romidepsin, or 500 nM Entinostat for 48 hours. The indicated proteins were measured by Western blot. Histone H3 serves as loading control.

  • 1/16

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2025 Jun 2;135(11):e187490. [Abstract]

    Customer Validation
     NSG mice were implanted with DNPC BCaP-1 PDXs and treated with vehicle, Fimepinostat (75 mg/kg orally, 5 times per week), or Romidepsin (1.5 mg/kg intraperitoneally, 2 times per week). Tumor volume (top) and mouse body weight (bottom) are shown.

  • 1/16

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2020 Oct 17;39(1):219. [Abstract]

    Customer Validation
     DNA damage detected by comet assay in SCLC cells upon treatment with 10 nM CUDC-907 or 10 μM olaparib alone and in combination for 48 h.

  • 1/16

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2020 Oct 17;39(1):219. [Abstract]

    Customer Validation
     Representative immunohistochemistry images of Ki67, cleaved-caspase3 (CC3), c-MYC, Rad51, and Ku80 on PDX tumors treated with CUDC-907 (75 mg/kg) and olaparib alone or in combination.

  • 1/16

    Fimepinostat mesylate purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2019 May;40(5):677-688. [Abstract]

    Customer Validation
     Aspc-1 and Capan-1 cells are collected for Western blotting with the indicated antibodies after treatment with CUDC-907 for 48 h.

  • Fimepinostat mesylate