Diphenidol
Based on 1 publication(s) in Google Scholar
Diphenidol is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea.
For research use only. We do not sell to patients.
- CAS No.: 972-02-1
- Formula: C21H27NO
- Molecular Weight:309.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Diphenidol
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Biological Activity
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mAChR1 |
mAChR2 |
mAChR3 |
mAChR4 |
Diphenidol inhibits sodium currents and produces spinal anesthesia, and at -70 and -100 mV holding potentials, N2A cells IC50 were 0.77 and 62.6 μM, respectively [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Diphenidol (30 mg/kg, injected intravenously) has an inhibitory effect on exercise and morphine-induced vomiting in pica rats[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Chronic constriction injury (CCI) rat model[4]
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Dosage:2, 10 μmoL/kg
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Administration:i.p., berore surgery, and on postoperative days 3, 6, 7, 11, 13 and 14.
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Result:Increased mechanical withdrawal threshold in a dose-dependent manner and decreased the TNF-α level.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 972-02-1
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Molecular Weight 309.45
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Formula C21H27NO
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SMILES
OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
Bile Canalicular Bitter Taste Receptors Inhibit β-Adrenergic Receptor-Induced Lipolysis in Steatotic Hepatocytes. [Abstract]2026 Apr 2;27(7):3226. PMID: 41977407
Purity & Documentation
References
[1]. Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44. [Content Brief]
[2]. Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52. [Content Brief]
[3]. Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52. [Content Brief]
[4]. Chen YW, et al. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27;552:62-5. [Content Brief]
[5]. Takeda N, et al. Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats. Methods Find Exp Clin Pharmacol. 1995 Nov;17(9):589-90. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Diphenidol Related Classifications
HY-A0270 Related Classifications
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