Cat. No.: HY-103400

8-Chloroadenosine

(Synonyms: 8-Cl-Ado)

1 Cited Publications

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8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice.

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Pureté: 99.75%
CAS No.: 34408-14-5
Formule: C₁₀H₁₂ClN₅O₄
Masse moléculaire:301.69

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

8-Chloroadenosine Chemical Structure

CAS No.: 34408-14-5

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

AMPK

Voir tous les produits spécifiques à Isoform AMPK :

Cellular Effect

Cell Line	Type	Value	Description	References
CAKI-1	IC₅₀	2 μM Compound: 8-Cl adenosine	Antiproliferative activity against human CAKI-1 cells assessed as reduction in cell proliferation incubated for 96 hrs by Cell TiterGlo assay Antiproliferative activity against human CAKI-1 cells assessed as reduction in cell proliferation incubated for 96 hrs by Cell TiterGlo assay	[PMID: 32942072]

In Vitro

8-Chloroadenosine (8-Cl-Ado; 10 μM; 24-72 hours) induces an autophagic flux in both LC3B-II and p62 levels^[1].
8-Chloroadenosine (10 μM; 7-21 hours) induces phosphorylation of AMPK (Thr172) in a time-dependent manner in MCF-7 and BT-474 cells. Total AMPK protein levels were unchanged. 8-Chloroadenosine readily induces the phosphorylation of raptor Ser792 in MCF-7 cells. 8-Chloroadenosine (10 μM; 4-72 hours) induces ULK1 phosphorylation on Ser555 in MCF-7 and BT-474 cells^[1].
8-Chloroadenosine attenuates mTOR activity in breast cancer cells. 8-Chloroadenosine is independent of p53^[1].
8-Chloroadenosine (10 μM; 3 days) inhibits over 90% clonogenic survival in the MCF-7 breast cancer cell lines. The amount of apoptosis induction only reached ~30%^[1].
8-Chloroadenosine (10 μM) treatment results in a rapid depletion of ATP within 12-hours in T47D, SK-BR-3, and ZR-75-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

8-Chloroadenosine (25-100 mg/kg; IP; three times a week for 3 weeks) inhibits growth of both MCF-7 and BT-474 xenograft tumors with 100 mg/kg. 8-Chloroadenosine with 50 mg/kg dose does not affect the growth of the BT-474 xenograft tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 34408-14-5
Appearance Solid
Masse moléculaire 301.69
Formule C₁₀H₁₂ClN₅O₄
Color White to off-white
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO
Synonyms

8-Cl-Ado
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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bioRxiv

2025 Nov 20.

Solvant et solubilité

In Vitro:

DMSO : 125 mg/mL (414.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3147 mL

16.5733 mL

33.1466 mL

5 mM

0.6629 mL

3.3147 mL

6.6293 mL

10 mM

0.3315 mL

1.6573 mL

3.3147 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Calculateur de dilution

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Christine M Stellrecht, et al. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3147 mL	16.5733 mL	33.1466 mL	82.8665 mL
	5 mM	0.6629 mL	3.3147 mL	6.6293 mL	16.5733 mL
	10 mM	0.3315 mL	1.6573 mL	3.3147 mL	8.2867 mL
	15 mM	0.2210 mL	1.1049 mL	2.2098 mL	5.5244 mL
	20 mM	0.1657 mL	0.8287 mL	1.6573 mL	4.1433 mL
	25 mM	0.1326 mL	0.6629 mL	1.3259 mL	3.3147 mL
	30 mM	0.1105 mL	0.5524 mL	1.1049 mL	2.7622 mL
	40 mM	0.0829 mL	0.4143 mL	0.8287 mL	2.0717 mL
	50 mM	0.0663 mL	0.3315 mL	0.6629 mL	1.6573 mL
	60 mM	0.0552 mL	0.2762 mL	0.5524 mL	1.3811 mL
	80 mM	0.0414 mL	0.2072 mL	0.4143 mL	1.0358 mL
	100 mM	0.0331 mL	0.1657 mL	0.3315 mL	0.8287 mL

Keywords

8-Chloroadenosine

1 Cited Publications

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8-Chloroadenosine

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Publications Citing Use of MedChemExpress (MCE) 8-Chloroadenosine

Voir tous les produits spécifiques à Isoform AMPK

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

8-Chloroadenosine Related Classifications

HY-103400 Related Classifications