AGH-194
AGH-194 is a 5-HT7 receptor agonist with a Ki value of 2 nM. AGH-194 activates Gs protein-coupled signaling pathways associated with neuroprotection and neurite outgrowth, and stimulates neurite outgrowth in neuronal cells. AGH-194 reduces cell damage in undifferentiated neuronal cells. AGH-194 can be used in the research of neurodegenerative diseases.
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- Fòrmula: C12H10ClFIN3
- Peso molecular:377.58
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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5-HT7 Receptor 2 nM (Ki) |
AGH-194 (0.1-80 μM; 24-48 h) induces concentration- and time-dependent cytotoxicity and reduced cell viability in UN-SH-SY5Y cells cultured in DMEM, with maximal effects at concentrations ≥40 μM[1].
AGH-194 (0.01-1 μM; 30 min pre-incubation, 24 h co-incubation with H2O2) at 0.1 μM partially reduces cytotoxicity but not cell viability loss in UN-SH-SY5Y cells cultured in NB exposed to H2O2-induced damage[1].
AGH-194 (0.01-0.1 μM; 24 h) stimulates neurite outgrowth in SH-SY5Y cells after 24 h, with no significant effects observed after 48 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Undifferentiated human neuroblastoma UN-SH-SY5Y cells (DMEM experimental medium)
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Concentration:0.1, 1, 10, 20, 40, 80 μM
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Incubation Time:24 h, 48 h
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Result:Caused a concentration- and time-dependent decrease in cell viability, with maximum damage observed at 40 and 80 μM; viability was more reduced at 48 h than 24 h for 20 and 40 μM.
Increased LDH release ~2-4-fold at 40 and 80 μM after 24 h.
Increased LDH release ~1.5-3-fold at 10, 20, 40, 80 μM after 48 h.
Showed higher LDH release at 48 h than 24 h for 20 and 40 μM, but higher at 24 h than 48 h for 80 μM.
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Cell Line:Undifferentiated human neuroblastoma UN-SH-SY5Y cells, retinoic acid-differentiated RA-SH-SY5Y cells (NB experimental medium)
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Concentration:1-20 μM
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Incubation Time:24 h
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Result:Caused a significant ~18% decrease in cell viability at 20 μM in UN-SH-SY5Y cells.
Caused a significant ~15.7% decrease in cell viability at 10 μM in RA-SH-SY5Y cells.
Caused a significant ~22.95% decrease in cell viability at 20 μM in RA-SH-SY5Y cells.
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Cell Line:Human neuroblastoma SH-SY5Y cells (DMEM with 10% FBS)
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Concentration:0.001, 0.01, 0.1, 1, 10, 20, 40, 80 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Caused a time- and concentration-dependent reduction in cell viability.
Induced maximal cell damage at 80 μM after 24 h, with similar effects at 48 and 72 h.
Caused concentration-dependent decreases in cell viability (up to ~20%) at 10, 20, 40 μM at 48 h, with greater effects than at 24 h.
Caused a significantly greater reduction in cell viability at 40 μM at 72 h than at 48 h.
Chemical Information
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Peso molecular 377.58
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Fòrmula C12H10ClFIN3
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SMILES
FC1=C2C(NC=C2C3=C[NH+]=CN3C)=CC=C1I.[Cl-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AGH-194 Related Classifications
HY-181984 Related Classifications
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