country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-125230

Copy Link Print Information

CN427

CN427 is a quinazoline-based BRD4 inhibitor with a K_d of 66 nM for BRD4. CN427 is applicable to the research of leukemia.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2260887-54-3
Fòrmula: C₂₈H₂₈N₆O₃
Peso molecular:496.57

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

CN427 Chemical Structure

No. CAS: 2260887-54-3

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

CN427 is a quinazoline-based BRD4 inhibitor with a K_d of 66 nM for BRD4. CN427 is applicable to the research of leukemia^[1].

IC₅₀ & Target^[1]

BRD4

66 nM (Kd)

Ver todos los productos específicos de isoformas Epigenetic Reader Domain :

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	1.1 μM Compound: 65; CN427	Cytotoxicity against human MV411 cells after 72 hrs by CellTiter-Glo assay Cytotoxicity against human MV411 cells after 72 hrs by CellTiter-Glo assay	[PMID: 30268702]
MV4-11	IC₅₀	1.1 μM Compound: 8	Cytotoxicity against human MV4-11 cells assessed as inhibition of cell viability Cytotoxicity against human MV4-11 cells assessed as inhibition of cell viability	[PMID: 30905542]

In Vitro

CN427 inhibits MV4-11 cell viability with an IC₅₀ of 1.10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC_0-∞	Bioavailability	V_ss	CL_plasma
Mice^[1]	2 mg/kg	i.v.	3.1 h	1690 ng/mL	1757 ng·h/mL	/	1.7 L/kg	19.8 mL/min/kg
Mice^[1]	10 mg/kg	p.o.	2.1 h	934 ng/mL	4494 ng·h/mL	51 %	/	/

Chemical Information

No. CAS 2260887-54-3
Peso molecular 496.57
Fòrmula C₂₈H₂₈N₆O₃
SMILES

OCCN1N=CC(=C1)C2=NC=3C=CC(=CC3C(=N2)N4CCOCC4C=5C=CC=CC5)C=6C(=NOC6C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang SM, et al. Discovery and lead identification of quinazoline-based BRD4 inhibitors. Bioorg Med Chem Lett. 2018;28(21):3483-3488. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

CN427

Ver todos los productos específicos de isoformas Epigenetic Reader Domain

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

CN427 Related Classifications

HY-125230 Related Classifications