CPUY201112
CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research.
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- No. CAS: 1860793-58-3
- Fòrmula: C19H23N3O4
- Peso molecular:357.40
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.76 μM
Compound: 50
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Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 27933959] |
| MCF7 | IC50 |
0.62 μM
Compound: 50
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 27933959] |
In Vitro
CPUY201112 (0-9 μM, 7 days) reduces the viability of multiple cancer cell lines such as HCT116 colon cells, HepG2 hepatocellular carcinoma and other cancer cells in a dose-dependent manner[1].
CPUY201112 (0-2 μM, 24 h) can induce apoptosis in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116, HepG2, MCF-7, A549
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Concentration:0-9 μM
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Incubation Time:7 days
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Result:Inhibited MCF-7, A549, HCT116 and HepG2 cells with the IC50 values of 0.624, 0.543, 0.763 and 0.342 μM, respectively.
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Cell Line:MCF-7 and HCT116 cells
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Concentration:0-2 μM
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Incubation Time:24 h
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Result:Induced cell cycle arrest in G2/M phase and induced apoptosis in more than 35% of MCF-7 cells.
Induced p53-mediated apoptosis in HCT116 cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c nude mice with MCF-7 cell[1]
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Dosage:5 mg/kg, 20 mg/kg and 40 mg/kg
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Administration:i.p., daily, 3 weeks
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Result:Reduced tumor volume by 11.92%, 26.58% and 39.63%, respectively, when using 5 mg/kg, 20 mg/kg and 40 mg/kg.
Significantly induced the expression of Hsp70 and reduced the expression of Akt at 40 mg/kg.
Chemical Information
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No. CAS 1860793-58-3
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Peso molecular 357.40
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Fòrmula C19H23N3O4
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SMILES
O=C(N1CCC2=NC(OCC)=NC=C2C1)C3=CC(C(C)C)=C(C=C3O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CPUY201112 Related Classifications
HY-111524 Related Classifications
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