Dasatinib-d8
Based on 1 publication(s) in Google Scholar
Dasatinib-d8 (BMS-354825-d8) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.07%
- No. CAS: 1132093-70-9
- Fòrmula: C22H18D8ClN7O2S
- Peso molecular:496.05
-
Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
-
Help & FAQs
-
HY-10181
DasatinibSrc/Bcr-Abl Inhibitor -
HY-10159
NilotinibBcr-Abl Inhibitor -
HY-12047
PonatinibMulti-targeted Kinase Inhibitor -
HY-13076
CHIR-98014GSK-3 Inhibitor -
HY-10159S
Nilotinib-d6Bcr-Abl Inhibitor -
HY-15200
AgerafenibBRAF Inhibitor -
HY-13342AS
Apatinib-d8 free baseStable Isotope -
HY-12964
SGI-7079Axl Inhibitor -
HY-18507A
AD57 hydrochlorideRET/BRAF/S6K/Src Inhibitor
Publications Citing Use of MedChemExpress (MCE) Dasatinib-d8
More
Actividad biológica
Descripciòn
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
No. CAS 1132093-70-9
-
Unlabeled CAS 302962-49-8
-
Appearance Solid
-
Peso molecular 496.05
-
Fòrmula C22H18D8ClN7O2S
-
Color White to off-white
-
SMILES
O=C(C1=CN=C(NC2=NC(C)=NC(N3C([2H])([2H])C([2H])([2H])N(CCO)C([2H])([2H])C3([2H])[2H])=C2)S1)NC4=C(C)C=CC=C4Cl
-
Synonyms
BMS-354825-d8
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
J Chromatogr B Analyt Technol Biomed Life Sci
Development of a validated and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method to simultaneous determination of crizotinib, alectinib and lorlatinib in human plasma. [Abstract]2025 Dec 15:1267:124770. PMID: 40902417
Solvente y solubilidad
In Vitro:
DMSO : 250 mg/mL (503.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
-
Ficha de datos (248 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
Instrucciones de manejo (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0159 mL | 10.0796 mL | 20.1593 mL | 50.3981 mL |
| 5 mM | 0.4032 mL | 2.0159 mL | 4.0319 mL | 10.0796 mL | |
| 10 mM | 0.2016 mL | 1.0080 mL | 2.0159 mL | 5.0398 mL | |
| 15 mM | 0.1344 mL | 0.6720 mL | 1.3440 mL | 3.3599 mL | |
| 20 mM | 0.1008 mL | 0.5040 mL | 1.0080 mL | 2.5199 mL | |
| 25 mM | 0.0806 mL | 0.4032 mL | 0.8064 mL | 2.0159 mL | |
| 30 mM | 0.0672 mL | 0.3360 mL | 0.6720 mL | 1.6799 mL | |
| 40 mM | 0.0504 mL | 0.2520 mL | 0.5040 mL | 1.2600 mL | |
| 50 mM | 0.0403 mL | 0.2016 mL | 0.4032 mL | 1.0080 mL | |
| 60 mM | 0.0336 mL | 0.1680 mL | 0.3360 mL | 0.8400 mL | |
| 80 mM | 0.0252 mL | 0.1260 mL | 0.2520 mL | 0.6300 mL | |
| 100 mM | 0.0202 mL | 0.1008 mL | 0.2016 mL | 0.5040 mL |
Dasatinib-d8 Related Classifications
HY-10181S Related Classifications
Powered by Bioz