DD202-114
Based on 1 Customer Validation
DD202-114 is a potent and selective GLP1R agonist. DD202-114 inhibits hERG with an IC50 of 15.9 μM. DD202-114 exhibits strong CYP2C8 inhibition with an IC50 of 0.22 μM. DD202-114 promotes cAMP accumulation. DD202-114 reduces blood glucose levels and food intake. DD202-114 has the potential to be used in the study of type 2 diabetes mellitus (T2DM) and obesity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.27%
- No. CAS: 2886728-09-0
- Fòrmula: C33H35FN4O5
- Peso molecular:586.65
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
|
CYP2C8 0.22 μM (IC50) |
In Vitro
Chemical Information
-
No. CAS 2886728-09-0
-
Appearance Solid
-
Peso molecular 586.65
-
Fòrmula C33H35FN4O5
-
Color White to off-white
-
SMILES
O=C(C1=CC=C2C(N(C(CN3CCC(C4=NC(OCC5=C(C=C(C=C5)C6COC6)F)=CC=C4)CC3)=N2)C[C@@H]7CCO7)=C1)O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 125 mg/mL (213.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (271 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Zhang Z, et al. Design and Evaluation of 3-Phenyloxetane Derivative Agonists of the Glucagon-Like Peptide-1 Receptor. J Med Chem. 2024 Sep 12;67(17):14820-14839. [Content Brief]
[2]. Dong G, et al. Discovery and Evaluation of DA-302168S as an Efficacious Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist. J Med Chem. 2025 May 8;68(9):9555-9583. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7046 mL | 8.5230 mL | 17.0459 mL | 42.6148 mL |
| 5 mM | 0.3409 mL | 1.7046 mL | 3.4092 mL | 8.5230 mL | |
| 10 mM | 0.1705 mL | 0.8523 mL | 1.7046 mL | 4.2615 mL | |
| 15 mM | 0.1136 mL | 0.5682 mL | 1.1364 mL | 2.8410 mL | |
| 20 mM | 0.0852 mL | 0.4261 mL | 0.8523 mL | 2.1307 mL | |
| 25 mM | 0.0682 mL | 0.3409 mL | 0.6818 mL | 1.7046 mL | |
| 30 mM | 0.0568 mL | 0.2841 mL | 0.5682 mL | 1.4205 mL | |
| 40 mM | 0.0426 mL | 0.2131 mL | 0.4261 mL | 1.0654 mL | |
| 50 mM | 0.0341 mL | 0.1705 mL | 0.3409 mL | 0.8523 mL | |
| 60 mM | 0.0284 mL | 0.1420 mL | 0.2841 mL | 0.7102 mL | |
| 80 mM | 0.0213 mL | 0.1065 mL | 0.2131 mL | 0.5327 mL | |
| 100 mM | 0.0170 mL | 0.0852 mL | 0.1705 mL | 0.4261 mL |
DD202-114 Related Classifications
HY-163996 Related Classifications
Powered by Bioz