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Referencia número: HY-139521S

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Doxepin-d₃

Doxepin-d₃ is the deuterium labeled Doxepin (HY-B0725A). Doxepin s an orally active tricyclic antidepressant agent. Doxepin is a potent and selective histamine receptor H1 antagonist. Doxepin is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2. Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis, chronic urticarial, can improve cognitive processes, protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress.

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No. CAS: 138387-16-3
Fòrmula: C₁₉H₁₈D₃NO
Peso molecular:282.39

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Doxepin-d₃ Chemical Structure

No. CAS: 138387-16-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Bioz

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Descripciòn

Ver todos los productos específicos de isoformas Cytochrome P450 :

Ver todos los productos específicos de isoformas Histamine Receptor :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aplicación

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

No. CAS 138387-16-3
Unlabeled Cas 1668-19-5
Peso molecular 282.39
Fòrmula C₁₉H₁₈D₃NO
SMILES

[2H]C([2H])([2H])N(C)CC/C=C1C2=CC=CC=C2COC3=CC=CC=C3/1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Doxepin-d3

Ver todos los productos específicos de isoformas Cytochrome P450

Ver todos los productos específicos de isoformas Histamine Receptor

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Referencias

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Doxepin-d3 Related Classifications

HY-139521S Related Classifications

Doxepin-d₃

Doxepin-d₃ Related Classifications