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Referencia número: HY-119110

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LY52

LY52 is an MMP-2 and MMP-9 inhibitor. LY52 can significantly block the proteolytic activity of gelatinases, reducing the expression of MMP-2 and MMP-9 in SKOV3 cells, thereby inhibiting cell invasion. LY52 can also suppress the pulmonary metastasis of Lewis lung carcinoma cells in mice. LY52 may be used in cancer research.

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No. CAS: 769970-91-4
Fòrmula: C₂₂H₂₄N₄O₆
Peso molecular:440.45

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

LY52 Chemical Structure

No. CAS: 769970-91-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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Chemical Information
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

MMP-9

MMP-2

Ver todos los productos específicos de isoformas MMP :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>1000 μM Compound: LY52	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 24755524]
A549	IC₅₀	78.25 μM Compound: LY52	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30093347]
C8166	CC₅₀	>454.37 μM Compound: LY52	Cytotoxicity against human C8166 cells after 72 hrs by MTT assay Cytotoxicity against human C8166 cells after 72 hrs by MTT assay	[PMID: 27039251]
C8166	EC₅₀	32.99 μM Compound: LY52	Antiviral activity against HIV1 3B infected in human C8166 cells assessed as cytopathic effect by counting the number of syncytia by microscopy Antiviral activity against HIV1 3B infected in human C8166 cells assessed as cytopathic effect by counting the number of syncytia by microscopy	[PMID: 27039251]
HeLa	IC₅₀	184.62 μM Compound: LY52	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30093347]
HL-60	IC₅₀	>1000 μM Compound: LY52	Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay	[PMID: 24755524]
HUVEC	CC₅₀	39.84 μM Compound: LY52	Cytotoxicity against HUVEC after 48 hrs by MTT assay Cytotoxicity against HUVEC after 48 hrs by MTT assay	[PMID: 30093347]
K562	IC₅₀	>200 μM Compound: LY52	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 30093347]
MCF7	IC₅₀	>200 μM Compound: LY52	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30093347]
MDA-MB-231	IC₅₀	>200 μM Compound: LY52	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 30093347]
SK-OV-3	IC₅₀	0.21 mM Compound: LY52	Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay	[PMID: 20097082]
SK-OV-3	IC₅₀	43.75 μM Compound: LY52	Inhibition of MMP2 in human SKOV3 cell suspension using succinylated gelatin as substrate preincubated for 10 mins before substrate addition measured after 30 mins by spectrophotometry Inhibition of MMP2 in human SKOV3 cell suspension using succinylated gelatin as substrate preincubated for 10 mins before substrate addition measured after 30 mins by spectrophotometry	[PMID: 24755524]
SK-OV-3	IC₅₀	697.14 μM Compound: LY52	Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay Antiproliferative activity against human SKOV3 cells after 48 hrs by MTT assay	[PMID: 24755524]

Chemical Information

No. CAS 769970-91-4
Peso molecular 440.45
Fòrmula C₂₂H₂₄N₄O₆
SMILES

O=C(N[C@@H]1CN([C@@H](C1)C(NO)=O)C(/C=C/C2=CC=C(C(OC)=C2)OC)=O)C3=CC=CN=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Qu X, et al. Caffeoyl pyrrolidine derivative LY52 inhibits tumor invasion and metastasis via suppression of matrix metalloproteinase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3573-8. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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LY52

Ver todos los productos específicos de isoformas MMP

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

LY52 Related Classifications

HY-119110 Related Classifications