ML 2-23
ML 2-23 is a potent PROTAC BCR-ABL degrader. ML 2-23 is selectively degrade BCR-ABL in a proteasome-dependent manner in leukemia cells.
(Pink: Bcr-Abl Target protein ligand; Blue: RNF114 ligand (HY-28328); Black: linker).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C47H53BrCl2N10O7S
- Peso molecular:1052.86
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
ML 2-23 (1 μM; 12 h; K562 cells) degrades BCR-ABL in a proteasome-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562 cells
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Concentration:1 μM
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Incubation Time:12 h
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Result:Degraded BCR-ABL in K562 cells.
Chemical Information
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Peso molecular 1052.86
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Fòrmula C47H53BrCl2N10O7S
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SMILES
O=C(COC1=CC=C(C2CC(C3=CC=C(Br)C=C3)=NN2C(CCl)=O)C=C1)NCCOCCOCCOCCN4CCN(C5=NC(C)=NC(NC6=NC=C(C(NC7=C(C)C=CC=C7Cl)=O)S6)=C5)CC4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML 2-23 Related Classifications
HY-153582 Related Classifications
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