MS-1020
MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling.
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- No. CAS: 1255516-86-9
- Fòrmula: C21H18N2O3
- Peso molecular:346.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
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JAK3 |
MS-1020 (0-50 µM; 24 h) inhibits STAT92E transcriptional activity in cultured Drosophila cells[1].
MS-1020 (0, 10, 30 , 50 µM) decreases the expression of tyrosine phosphorylated STAT3 levels and shows no changes on total STAT3 levels[1].
MS-1020 (0, 10, 30 , 50 µM; 16 h) decreases the expression of IL-2 (100 ng/ml)-induced STAT5 phosphorylation in Nb2 cells[1].
MS-1020 (0, 10, 30 , 50 µM; 72 h) promotes cell death in a time- and dose-dependent manner in L540 cells[1].
MS-1020 (0, 10, 30 , 50 µM; 72 h) induces apoptosis in L540 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L540, HDLM-2, MDA-MB-468 cells
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Concentration:0, 10, 30, 50 µM
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Incubation Time:
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Result:Decreased the expression of tyrosine phosphorylated STAT3 levels in a dose-dependent manner and showed no changes on total STAT3 levels.
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Cell Line:L540, HDLM-2 cells
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Concentration:0, 10, 30, 50 µM
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Incubation Time:72 h
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Result:Promoted cell death in a time- and dose-dependent manner only in L540 cells.
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Cell Line:L540 cells
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Concentration:0, 10, 30, 50 µM
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Incubation Time:72 h
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Result:Induced apoptosis in L540 cells and increased the expression of cleavage of Poly (ADP-ribose) polymerase (PARP) and cleaved caspase-3 and cleaved caspase-3, decreased the expression of Bcl-2, Bcl-xL, Mcl-1, and survivin in a dose-dependent manner.
Chemical Information
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No. CAS 1255516-86-9
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Peso molecular 346.38
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Fòrmula C21H18N2O3
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SMILES
O=C(C1=CC=C2C=CC=CC2=C1O)NCCC3=CNC4=C3C=C(O)C=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MS-1020 Related Classifications
HY-123099 Related Classifications
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