MS108

MS108 (1 nM-10 μM; 24 h) induces near-complete ENL degradation in MV4;11 cells, achieving 99% degradation at 1 μM after 24 h of treatment^[1].
MS108 (0.049-50 nM; 24 h) potently induces concentration-dependent ENL degradation in MV4;11 cells (DC₅₀ = 0.60 nM) and Jurkat cells (DC₅₀ = 1.13 nM) with near-maximal degradation (Dmax >97%) after 24 h of treatment^[1].
MS108 (30 nM; 10 min-72 h) rapidly induces time-dependent ENL degradation in MV4;11 cells (detectable within 10 min) and Jurkat cells (detectable within 20 min), with sustained degradation for up to 72 h at 30 nM^[1].
MS108 degrades ENL in MV4;11 cells in a VHL- and ubiquitin-proteasome system-dependent manner, without affecting ENL transcription^[1].
MS108 potently inhibits the proliferation of MV4;11 (GI₅₀ = 1.19 nM), RS4;11 (GI₅₀ = 4.68 nM), KASUMI1 (GI₅₀ = 5.89 nM), and SEMK2 (GI₅₀ = 43.16 nM) leukemia cell lines^[1].
MS108 (1-1000 nM; 24 h) is a highly selective degrader that efficiently targets ENL and AF9, but not YEATS2 or GAS41, in MV4;11 cells after 24 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.