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Referencia número: HY-157579

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MS154N

Name: MS154N
Brand: MedChemExpress
SKU: HY-157579
Price: 340.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

MS154N is the negative control of MS39 (HY-157581). MS154N binds to EGFR but does not induce EGFR degradation. MS154N can be used in the research of non-small cell lung cancer.
(Pink: EGFR ligand (HY-168305); Blue: Ligands for E3 Ligase ligand (HY-W441376); Black: linker (HY-168306)).

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.30%
No. CAS: 2675490-97-6
Fòrmula: C₄₇H₅₆ClFN₈O₈
Peso molecular:915.45

Almacenamiento:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

MS154N Chemical Structure

No. CAS: 2675490-97-6

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

MS154N is the negative control of MS39 (HY-157581). MS154N binds to EGFR but does not induce EGFR degradation. MS154N can be used in the research of non-small cell lung cancer^[1]. (Pink: EGFR ligand (HY-168305); Blue: Ligands for E3 Ligase ligand (HY-W441376); Black: linker (HY-168306)).

Ver todos los productos específicos de isoformas PROTACs :

Ver todos los productos específicos de isoformas EGFR :

In Vitro

MS154N (Compound 28) (30 μM) binds to purified wild-type EGFR and EGFR^L858R mutants with high affinity^[1].
MS154N does not induce degradation of mutant EGFR in HCC-827 or H3255 lung cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2675490-97-6
Appearance Solid
Peso molecular 915.45
Fòrmula C₄₇H₅₆ClFN₈O₈
Color White to off-white
SMILES

O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(OCCCCCCCCNC(CCN4CCN(CCCOC5=CC6=C(NC7=CC=C(C(Cl)=C7)F)N=CN=C6C=C5OC)CC4)=O)=CC=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Cheng M, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. Journal of medicinal chemistry. 2020 Feb 13;63(3):1216-1232. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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MS154N

Ver todos los productos específicos de isoformas PROTACs

Ver todos los productos específicos de isoformas EGFR