MS9449
Based on 1 Customer Validation
MS9449 is a potent PROTAC EGFR degrader with Kds of 17 nM and 10 nM for EGFR WT and EGFR L858R, respectively. MS9449 effectively induces degradation of mutant EGFRs through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9449 potently inhibits the proliferation of NSCLC cells. MS9449 can be used for researching anticancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.95%
- No. CAS: 2772612-96-9
- Fòrmula: C60H76ClFN10O8S
- Peso molecular:1151.82
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas PROTACs
MoreVer todos los productos específicos de isoformas EGFR
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Actividad biológica
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EGFR (WT) 17 nM (Kd) |
EGFR L858R 10 nM (Kd) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCC827 | GI50 |
0.25 μM
Compound: 31; MS9449
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Antiproliferative activity against human HCC827 cells assessed as cell growth inhibition incubated for 3 days by CCK-8 assay
Antiproliferative activity against human HCC827 cells assessed as cell growth inhibition incubated for 3 days by CCK-8 assay
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[PMID: 35675209] |
Chemical Information
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No. CAS 2772612-96-9
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Appearance Solid
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Peso molecular 1151.82
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Fòrmula C60H76ClFN10O8S
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Color White to light yellow
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SMILES
O=C([C@H]1N(C([C@@H](C2=CC(C)=NO2)C(C)C)=O)C[C@H](O)C1)N[C@H](C3=CC=C(C4=C(C)N=CS4)C=C3)CC(NCCCCCCCCCCC(N5CCN(CCCOC6=CC7=C(NC8=CC=C(F)C(Cl)=C8)N=CN=C7C=C6OC)CC5)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 200 mg/mL (173.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8682 mL | 4.3410 mL | 8.6819 mL | 21.7048 mL |
| 5 mM | 0.1736 mL | 0.8682 mL | 1.7364 mL | 4.3410 mL | |
| 10 mM | 0.0868 mL | 0.4341 mL | 0.8682 mL | 2.1705 mL | |
| 15 mM | 0.0579 mL | 0.2894 mL | 0.5788 mL | 1.4470 mL | |
| 20 mM | 0.0434 mL | 0.2170 mL | 0.4341 mL | 1.0852 mL | |
| 25 mM | 0.0347 mL | 0.1736 mL | 0.3473 mL | 0.8682 mL | |
| 30 mM | 0.0289 mL | 0.1447 mL | 0.2894 mL | 0.7235 mL | |
| 40 mM | 0.0217 mL | 0.1085 mL | 0.2170 mL | 0.5426 mL | |
| 50 mM | 0.0174 mL | 0.0868 mL | 0.1736 mL | 0.4341 mL | |
| 60 mM | 0.0145 mL | 0.0723 mL | 0.1447 mL | 0.3617 mL | |
| 80 mM | 0.0109 mL | 0.0543 mL | 0.1085 mL | 0.2713 mL | |
| 100 mM | 0.0087 mL | 0.0434 mL | 0.0868 mL | 0.2170 mL |
MS9449 Related Classifications
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