MTX-23
Based on 1 publication(s) in Google Scholar
MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis.
(Pink: AR-V7 Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.79%
- No. CAS: 2488296-74-6
- Fòrmula: C43H53F2N7O7S2
- Peso molecular:882.05
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Anti-Cancer Compound Library
HY-L025
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Transcription Factor-Targeted Library
HY-L090
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Anti-Prostate Cancer Compound Library
HY-L124
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Nuclear Receptor Compound Library
HY-L126
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PROTAC Library
HY-L151
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) MTX-23
MoreVer todos los productos específicos de isoformas PROTACs
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Actividad biológica
MTX-23 (compound 16; 0-20 μM; 4 d; 22Rvl cells) inhibits cell growth in dose-dependent manner[1].
MTX-23 (10 μM; 4 d; 22Rvl cells) reduces AR-V7 protein levels[1].
MTX-23 (1 μM; 0-48 h; 22Rvl cells) induces apoptosis and increases annexin-V staining[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:22Rvl cells
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Concentration:0-20 μM
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Incubation Time:4 days
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Result:Reduced the cell count by less than 50 percent.
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Cell Line:22Rvl cells
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Concentration:1 μM
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Incubation Time:0-48 h
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Result:Induced cell apoptosis in 22Rvl cells.
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Cell Line:22Rvl cells
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Concentration:10 μM
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Incubation Time:4 days
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Result:Reduced AR-V7 protein levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:nu/nu mice with 22Rvl-EnzR tumor xenografts[1]
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Dosage:2.5 mg/mL
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Administration:intratumor injection
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Result:Inhibited tumor growth in nu/nu mice with 22Rvl-EnzR tumor xenografts.
Chemical Information
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No. CAS 2488296-74-6
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Appearance Solid
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Peso molecular 882.05
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Fòrmula C43H53F2N7O7S2
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Color Off-white to light yellow
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SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
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Synonyms
PROTAC AR-V7 degrader-2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2026 Apr;652(8110):763-773. PMID: 41882358
Solvente y solubilidad
DMSO : 100 mg/mL (113.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1337 mL | 5.6686 mL | 11.3372 mL | 28.3431 mL |
| 5 mM | 0.2267 mL | 1.1337 mL | 2.2674 mL | 5.6686 mL | |
| 10 mM | 0.1134 mL | 0.5669 mL | 1.1337 mL | 2.8343 mL | |
| 15 mM | 0.0756 mL | 0.3779 mL | 0.7558 mL | 1.8895 mL | |
| 20 mM | 0.0567 mL | 0.2834 mL | 0.5669 mL | 1.4172 mL | |
| 25 mM | 0.0453 mL | 0.2267 mL | 0.4535 mL | 1.1337 mL | |
| 30 mM | 0.0378 mL | 0.1890 mL | 0.3779 mL | 0.9448 mL | |
| 40 mM | 0.0283 mL | 0.1417 mL | 0.2834 mL | 0.7086 mL | |
| 50 mM | 0.0227 mL | 0.1134 mL | 0.2267 mL | 0.5669 mL | |
| 60 mM | 0.0189 mL | 0.0945 mL | 0.1890 mL | 0.4724 mL | |
| 80 mM | 0.0142 mL | 0.0709 mL | 0.1417 mL | 0.3543 mL | |
| 100 mM | 0.0113 mL | 0.0567 mL | 0.1134 mL | 0.2834 mL |
MTX-23 Related Classifications
HY-148771 Related Classifications
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