NAS-181
Based on 3 publication(s) in Google Scholar
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions.
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- No. CAS: 205242-62-2
- Fòrmula: C20H30N2O7S
- Peso molecular:442.53
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Publications Citing Use of MedChemExpress (MCE) NAS-181
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Actividad biológica
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5-HT1B Receptor |
NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices[1].
NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:20 mg/kg
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Administration:S.c.
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Result:Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40−60%).
Chemical Information
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No. CAS 205242-62-2
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Peso molecular 442.53
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Fòrmula C20H30N2O7S
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SMILES
CS(=O)(O)=O.[C@H]1(COC2=C3C(C=C(CN4CCOCC4)CO3)=CC=C2)CNCCO1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Neurosci
Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety. [Abstract]2022 Dec;25(12):1651-1663. PMID: 36446933 -
Transl Neurodegener
Dorsal raphe nucleus-hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice. [Abstract]2024 Jul 24;13(1):34. PMID: 39044270 -
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NAS-181 Related Classifications
HY-135507 Related Classifications
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